Job Description:
Company Description
Eurofins Scientific is an international life sciences company, providing a unique range of analytical testing services to clients across multiple industries, to make life and our environment safer, healthier and more sustainable. From the food you eat, to the water you drink, to the medicines you rely on, Eurofins laboratories work with the biggest companies in the world to ensure the products they supply are safe, their ingredients are authentic and labelling is accurate.
The Eurofins network of companies is the global leader in food, environment, pharmaceutical and cosmetic product testing and in agroscience Contract Research Organisation services. It is one of the market leaders in certain testing and laboratory services for genomics, discovery pharmacology, forensics, advanced material sciences and in the support of clinical studies, as well as having an emerging global presence in Contract Development and Manufacturing Organisations. It also has a rapidly developing presence in highly specialised and molecular clinical diagnostic testing and in-vitro diagnostic products.
In over 30 years, Eurofins has grown from one laboratory in Nantes, France to 58,000 staff across a decentralised and entrepreneurial network of 900 laboratories in over 54 countries. Eurofins companies offer a portfolio of over 200,000 analytical methods to evaluate the safety, identity, composition, authenticity, origin, traceability and purity of biological substances and products.
In 2021, Eurofins generated total revenues of EUR 6.72 billion, and has been among the best performing stocks in Europe over the past 20 years.
Job Description
The purpose of this position is to develop high-throughput cutting-edge genomic technologies to better understand disease mechanism and to accelerate the discovery of new targets and biomarkers across therapeutic areas. The incumbent will utilize innovative genetic screening (CRISPR) and multi-omics single cell sequencing approaches (Optical pooled screening, CRISPR-Seq) to impact all stages of the pipeline from pre-clinical to clinical development. In the position, you will collaborate closely with Oncology, Immunology, Neuroscience, Cardiometabolic disease, Pharmacology, and Chemical Biology areas throughout the Discovery, Preclinical and Translational Medicine.
We areseeking a highly motivated scientist with expertise in cell and molecular biology, high-throughput genomic technologies, CRISPR screening and high content imaging to join our group in Cambridge, MA. The successful candidate will be an active participant in the scientific dialogue of the group and will be able to work independently and proactively collaborate with colleagues.
In this exciting role you will:
- Contribute to the planning and execution of experiments to discover new drug targets in multiple therapeutic areas
- Work with complex cellular models (primary cells, iPSC-derived cells, 2D and 3D coculture models) in addition to immortalized cell lines
- Assist in developing, executing, analyzing and troubleshooting newcell-based assays with disease-relevant phenotypes and determine feasibility and the best approach for CRISPR screens.
- Execute large-scale CRISPR screens in pooled and arrayed formats.
- Use gene editing and other genomic technologies (transcriptomics, proteomics) to validate potential drug targets.
- Communicate results and findings clearly and concisely to teams and stakeholders.
- Maintain detailed lab notebook and records of work,help the lab manager maintain laboratory equipment used for experiments.
- This position requires 90% of time in the lab.
Qualifications
Education and Work Experience Requirements:
•Ph.D. degree in cell and molecular biology or related scientific discipline or M.S. degree in cell
and molecular biology or related scientific discipline with 5+ years hands-on wet lab experience
in academia or industry
Required Experience and Skills
•Extensive hands-on experience in cell-based assay development, CRISPR-based screens
•Working knowledge and experience with high-content imaging assays
•Strong ability to troubleshoot and optimize novel methods and protocols
•Self-motivated and capable of prioritizing deliverables among multiple simultaneous projects
•Excellent attention to detail and strong communication skills
•Ability to work independently, but also build strong relationships within highly collaborative,
multidisciplinary teams to effectively drive early drug discovery initiatives
Preferred Experience and Skills:
•Demonstrated experience with high-content phenotypic screening
•Image analysis tools experience (e.g. Signals Image Artist)
•Experience with genomic technologies (NGS, scRNA-seq, CROP-seq/Perturb-seq)
•Drug Discovery experience in biotech and/or pharmaceutical industry
•Experience working in a highly matrixed organization
Additional Information
What we offer:
- Excellent full time benefits including comprehensive medical coverage, dental, and vision options
- Life and disability insurance
- 401(k) with company match
- Paid vacation and holidays
- Career Development and continuing education opportunities
Eurofins Lancaster Laboratories Professional Scientific Services®(PSS) is a global, award-winning insourcing solution that places our people at our clients' site dedicated to running and managing laboratory services while eliminating headcount, co-employment and project-management worries.
We infuse our 55-year track record of scientific and laboratory operations expertise, as well as HR and great place to work best practices, to recruit, hire, train and manage highly qualified scientists to perform laboratory services using our client's quality systems and equipment.
Eurofins is aM/F, Disabled, and Veteran Equal Employment Opportunity and Affirmative Action employer.
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