DMPK Scientist Project Team Representative at Alexion in New Haven, Connecticut

Job Description:

This is what you will do:



Alexion Pharmaceuticals, AstraZeneca Rare Disease, is seeking an experienced DMPK scientist and dedicated drug hunter to join the small molecule team located in New Haven, CT. In this position you will play a pivotal role in providing expertise and troubleshooting to the active discovery small molecule projects as well as providing mentorship to fellow scientists within the DMPK group.



You will be responsible for:

• Working closely with the medicinal chemistry team, you will lead the DMPK efforts aiding in troubleshooting and guidance to the discovery project team with a particular focus on optimizing properties for oral administration


• Represent the DMPK function in collaborations with wider groups within Alexion and AZ including the discovery and small molecule biology teams


• Provide subject matter expertise in the Interpretation of DMPK experimental data related to the in vitro and in vivo animal PK, biotransformation, and IVIVC analysis. Present regularly to peers and senior leaders


• Mentor/train colleagues and/or team on in vitro ADME and in vivo animal PK analysis (Winnolin)


• Coordinate outsourced in vitro and in vivo DMPK studies as needed


• Develop new technologies and capabilities in discovery DMPK space


• Guide junior scientists and manage a dynamic and engaging a team!

You will need to have:

• Broad knowledge of drug metabolism and pharmacokinetics and experience in applying this to successful small molecule drug discovery as a DMPK scientist


• An expert understanding of DMPK, physic-chemical property assays and biotransformations required to support discovery small molecule projects


• Strong collaboration and innovative skills across subject areas representing DMPK as a project team representative within the core team is a key requirement


• Experience in the design, conduct, and interpretation of in vitro and in vivo ADME and animal PK studies


• The duties of this role are generally conducted in an office/lab environment. As is typical of an office/lab-based role, employees must be able, with or without an accommodation to: lift/carry 10/20 pounds unassisted/assisted; work comfortably in an environment with and around chemical, biological, and hazardous materials; gown/degown PPE; use a computer; engage in communications via phone, video, and electronic messaging; maintain general availability during standard business hours.

We would prefer for you to have:

• PhD in Drug Metabolism, Pharmacokinetics, Chemistry, or a related scientific field with 5 years of industry experience post PhD


• Supported Drug Discovery with specific expertise in small molecule discovery DMPK


• Experience in leading, mentoring, and training junior scientists!

Expectation of working in the office 4 days a week statement: When we put unexpected teams in the same room, we unleash bold thinking with the power to inspire life-changing medicines. In-person working give us the platform we need to connect, work at pace and challenge perceptions. That's why we work, on average, a minimum of four days per week from the office. But that doesn't mean we're not flexible. We balance the expectation of being in the office while respecting individual flexibility. Join us in our unique and ambitious world.



Date Posted

15-Mar-2024



Closing Date

25-Jul-2024Alexion is proud to be an Equal Employment Opportunity and Affirmative Action employer. We are committed to fostering a culture of belonging where every single person can belong because of their uniqueness. The Company will not make decisions about employment, training, compensation, promotion, and other terms and conditions of employment based on race, color, religion, creed or lack thereof, sex, sexual orientation, age, ancestry, national origin, ethnicity, citizenship status, marital status, pregnancy, (including childbirth, breastfeeding, or related medical conditions), parental status (including adoption or surrogacy), military status, protected veteran status, disability, medical condition, gender identity or expression, genetic information, mental illness or other characteristics protected by law. Alexion provides reasonable accommodations to meet the needs of candidates and employees. To begin an interactive dialogue with Alexion regarding an accommodation, please contact accommodations@Alexion.com. Alexion participates in E-Verify.


AstraZeneca requires all US employees to be fully vaccinated for COVID-19 but will consider requests for reasonable accommodations as required by applicable law. Apply Now