Scientist: Cell Line Development, CHO Protein Vaccines at Thermo Fisher Scientific in Rockville, Maryland

Job Description:

Work Schedule

Standard (Mon-Fri)



Environmental Conditions

Some degree of PPE (Personal Protective Equipment) required (safety glasses, gowning, gloves, lab coat, ear plugs etc.)



Job Description



Thermo Fisher's clinical research business is a leading global contract research organization and world leader in serving science. We are passionate, deliberate, and driven by our mission - to enable our customers to make the world healthier, safer, and cleaner.


Within our Analytical Services team, we have a functional service provider solution, which is a unique partnership that allows our customers to maximise the experience of our staff, while allowing you, the employee, to gain direct experience working onsite at a pharmaceutical/ biopharmaceutical company, all while maintaining full-time benefits.



Essential Functions:



The target client is a leading pharmaceutical group responsible for the development of CHO based production cell lines, next-gen cell line engineering efforts and baseline upstream process development for innovative recombinant protein/adjuvanted vaccine projects and platforms. The target client is looking for a motivated professional, specialized in commercial cell line development, CHO protein vaccines. This role will play a significant role in shaping current and next generation leading vaccine platforms to accelerate addressing unmet medical needs, an exciting field having a direct impact into patients and global health. This role provides the opportunity to integrate a diverse group of top dedicated experts in vaccines' industry, lead key activities and further grow and progress in your career.



Main core responsibilities:

A. Design and Development of preGMP-grade CHO cell lines for commercial manufacture of recombinant protein vaccine products.


B. Serve as a key teammate to support project documentation and CMC regulatory submissions (including raw material control section and cell line derivation report)



Education and Experience:



Bachelor's degree in a degree related in Biochemistry, Molecular Biology, Chemical Engineering, Biotechnology, Bioengineering, or a related scientific field.

• Previous proven experience that provides the knowledge, skills, and abilities to perform the job:


• Scientist: With a bachelor's degree comparable to 2+ years

• Hands-on experience with aseptic mammalian (CHO cell preferred) cell line development, especially transfection, single cell isolation, derivation, suspension cell culture at small scales ranging including 96 well-plate, 24 well-plate and shake flask formats.


• Experience with expression vector design and optimization for complex recombinant protein production.


• Experience with good documentation practices and reports as evidenced by conference proceeding, peer-review publication and/or equivalent.

In some cases, an equivalency, consisting of a combination of appropriate education, training and/or directly related experience, will be considered sufficient for an individual to meet the requirements of the role.



Preferred Qualifications:

• Solid understanding in the cell line development for vaccine and biologicals production in the industrial setting (including a strong CMC understanding)


• Prior experience in the high-throughput, robotic cell line screening tools (including FACS and Beacon et al) or other high-throughput robotic systems
  


• Experience with common nucleic acid- and protein-based analytic assays (including PCR, Luminex and Octet) for early product quantity and quality assessment to support cell line selection. .

Working Environment:

• PPD values the health and well being of our employees. We support and encourage individuals to create a healthy and balanced environment where they can thrive. Below is listed the working environment/requirements for this role:


• Able to communicate, receive, and understand information and ideaswith diverse groups of peoplein a comprehensible and reasonable manner.


• Ableto work upright and stationary and/or standingfor typical working hours.


• Able to lift and move objects up to 25 pounds


• Able to work in non-traditional work environments.


• Able to use and learn standard office equipment and technologywith proficiency.


• May have exposure to potentially hazardous elements, including infectious agents, typically found in healthcare or laboratory environments.


• Able to perform successfully under pressure while prioritizing and handling multiple projects or activities.

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