PhD in Biochemistry, Biomedical/Chemical Engineering, Immunology, or related field with minimum of 2 years of post-graduate experience (preferably in industry), MS with 8+ years of research experience, BS with 10+ years of research experience in antibody or protein engineering • Significant experience in antibody discovery and protein engineering by using single B cell cloning, hybridoma, or phage/yeast display techniques • Strong background in molecular biology, antibody and protein expression, and biophysical characterization of recombinant antibodies and proteins • Demonstrated experience in working collaboratively across various scientific disciplines and other parts of the organization to meet end goals • Highly motivated individual with exceptionally good organizational skills, and attention to details • Demonstrate ability to succeed in a fast-paced environment, working on multiple projects with constantly changing priorities and deadlines • Excellent written and verbal communication skills • Strong interpersonal skills
ADDITIONAL PREFERENCES • Experience in single domain antibodies, multi-specific antibody engineering, Fc engineering, antibody drug conjugates, naïve phage or yeast display library design • Experience in NGS analysis for antibody discovery and engineering • Significant contributions to successful biologics drug discovery programs in biotech/biopharma industry
Responsibilities:
Design strategies and execute antibody discovery campaigns for therapeutic and reagent antibodies using phage display • Generate antibody fragment libraries for antibody discovery and engineering, perform HT binding screens (ELISA and multi-plex flow cytometry) and sequence analysis to generate hits • Rank-order clones by affinity, in vitro potency, and early developability assessment • Execute sequence optimization of lead antibodies to improve developability and binding affinity • Design and clone constructs for mAbs, bispecific, and multi-specific antibodies for recombinant antibody production • Support NGS-based antibody discovery workflow • Present data and updates to management and project teams • Follow good documentation practice including maintaining good record keeping in Electronic Notebooks