Scientist, mAb Prep Lab/Downstream Process Development at Zoetis in Kalamazoo, Michigan

Job Description:

Role Description



The candidate will work in the Protein Preparation Laboratory and Downstream Process Development group within Biologics Process Development of Zoetis Development Sciences and Technologies.


The successful applicant will work with other team members to produce multiple preparations of monoclonal antibodies and therapeutic proteins in a fast-paced R&D space engaged in numerous projects. The incumbent is expected to work hands-on at the bench while learning strong technical skills in both upstream production and downstream purification workflows.


They are expected to work in partnership with colleagues in upstream/downstream development, formulation development, and bioanalytical science. In addition, the candidate will be expected to maintain Good Documentation Practices in support of global regulatory submissions for product licensure. Moreover, they will be involved in identification and development of new technologies and will provide support to Downstream and Upstream development. They will also assist with new product transfers to Biological Manufacturing sites within Zoetis.



Additional duties and responsibilities include:

• Aseptically culture cells and production systems such as CHO cells for the expression of monoclonal antibodies (mAb) and recombinant proteins.


• Operate bench- and mid-scale bioreactor systems that are used within the laboratory to routinely produce mAbs and therapeutic proteins.


• Operate multiple modalities of chromatography and filtration systems that are routinely used to isolate, purify, and concentrate mAbs and proteins.


• Coordinate with cell culture and downstream development groups on the procedures, raw materials and equipment required for a successful mid-scale batch.


• Learn to serve as a company resource in protein isolation, purification, and scaling of bioreactor systems and downstream processes as it relates to manufacturing processes.


• Serve as a technical liaison between Biologics Process Development - Downstream Development group, Upstream Development team, and other partner groups such as Discovery, Pilot, GMS and Regulatory.


• Establish a network within Zoetis and with key suppliers and institutions to serve business needs, and provide cost effective, innovative solutions for Zoetis.


• Regularly communicate via excellent written and verbal interactions, as well as clear technical presentations to project teams and management.


• Work within GLP/cGMP documentation standards to provide high quality, regulatory compliant technical documentation in support of technology transfer within the company or to contract manufacturers and well as to support regulatory filings for new product registrations.


• Strive for continuous improvement in the existing workflow, technologies, and techniques utilized in bioprocess development.


• Maintain electronic laboratory notebooks and records in accord with scientific protocol and applicable Standard Operating Procedures.


• Demonstrate excellent organizational skills in order to engage in multiple projects.


• Bolster the highly collaborative team environment necessary across the biopharmaceutical development programs.

The position is based in Kalamazoo (Michigan, USA) with interactions with colleagues and external partners located around the globe.




Qualifications:




Educational Background:

• Minimum: B.S. Biochemistry, Biotechnology, Chemical/Biochemical Engineering, or a related field


• Preferred: BS with 3-8 years of experience or MS with 0-6 years of experience

Work Experience/Skills:




Minimum:

• Familiarity/Experience in multiple types of low pressure chromatography development.


• Familiarity/Experience in crossflow and dead-end filtration development.


• Familiarity/Experience in the purification of monoclonal and hybridoma antibodies.


• Familiarity/Experience with basic analytical methods which may include HPLC, gel electrophoresis, and total protein analysis.


• Familiarity/Experience in aseptic technique and cell culture.


• Familiarity/Experience in bioreactor/fermenter operation.


• Strong communication skills, both oral and written. Strong interpersonal skills, ability to work effectively with all types of personalities.

Desirable:

• Experience with mid-scale and/or large scale protein/vaccine preparations.


• Experience with Design of Experiments (DOE) planning, execution, and analyzing data.


• Experience with automated chromatography systems such as AKTA.


• Experience with principles of scale-up and scale-down to bioreactor systems and downstream processes.


• Knowledge of regulatory issues associated with USDA and EU biologics submissions.


• Knowledge of GXPs, including Process validation.

Other Attributes Desirable:

• Highly computer literate. Capable of quickly learning and adapting to new computer programs.


• Experience with technical transfers.


• Ability to multi-task; working on multiple projects simultaneously.


• Team player, positive attitude, good organizational skills, and highly motivated.

Full time


Regular


Colleague


Any unsolicited resumes sent to Zoetis from a third party, such as an Agency recruiter, including unsolicited resumes sent to a Zoetis mailing address, fax machine or email address, directly to Zoetis employees, or to Zoetis resume database will be considered Zoetis property. Zoetis will NOT pay a fee for any placement resulting from the receipt of an unsolicited resume.


Zoetis will consider any candidate for whom an Agency has submitted an unsolicited resume to have been referred by the Agency free of any charges or fees. This includes any Agency that is an approved/engaged vendor but does not have the appropriate approvals to be engaged on a search.


Zoetis is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status or any other protected classification. Disabled individuals are given an equal opportunity to use our online application system. We offer reasonable accommodations as an alternative if requested by an individual with a disability. Please contact Zoetis Colleague Services at zoetiscolleagueservices@zoetis.com to request an accommodation. Zoetis also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as employment eligibility verification requirements of the Immigration and Nationality Act. All applicants must possess or obtain authorization to work in the US for Zoetis. Zoetis retains sole and exclusive discretion to pursue sponsorship for the acquisition or maintenance of nonimmigrant status and employment eligibility, considering factors such as availability of qualified US workers. Individuals requiring sponsorship must disclose this fact. Please note that Zoetis seeks information related to job applications from candidates for jobs in the U.S. solely via the following: (1) our company website at www.Zoetis.com/careers site, or (2) via email to/from addresses using only the Zoetis domain of "@zoetis.com". In addition, Zoetis does not use Google Hangout for any recruitment related activities. Any solicitation or request for information related to job applications with Zoetis via any other means and/or utilizing email addresses with any other domain should be disregarded. In addition, Zoetis will never ask candidates to make any type of personal financial investment related to gaining employment with Zoetis. Apply Now