Come join Alphina Therapeutics - Precision Medicine for Cancer Metabolic Deficiencies (alphinatx.com), a Connecticut Innovations portfolio company!
Looking for someone to be onsite 3 to 4 days a week in New Haven
Alphina Therapeutics
Alphina Therapeutics is an early-stage biopharma company founded by world class scientists and backed by a strong syndicate of venture capitalists. Based on the work of Alphina's founders, the company is developing a first-in-class small molecule inhibitor of a metabolic pathway to treat a variety of solid tumors. Alphina is also developing a proprietary companion diagnostic to enable selection of patients whose tumors harbor perturbations which make their tumor exquisitely sensitive to Alphina's lead compounds. Approximately 30% of all solid tumors display this perturbation and would therefore be a candidate for Alphina's drug. The company aims to enter the clinic in early 2026. Alphina plans to test their drug candidate in multiple tumor types, which could enable a development path to address a very large market.
Alphina is located at the Elm City Bioscience Center (ECBC) at 55 Church St in New Haven, next to Yale's campus and easily accessible from both New York and Boston.
Head of Biology and Pharmacology (Director/Sr. Director)
You will be responsible for leading a small team of talented biologists, and be accountable for the design and implementation of pre-clinical in vitro and in vivo studies supporting the identification and advancement of our drug candidates. Responsibilities include management of external biology resources at contract research organizations (CROs), managing ADME, toxicology, in vitro and in vivo screening models, and assessing the pharmacodynamic and functional efficacy of compounds. The successful candidate will work closely with our SVP Medicinal Chemistry as well as the company's SAB and members of the Board of Directors. This role provides an opportunity to join an exciting fast-paced company using cutting-edge science to address a significant medical and market opportunity.
Qualifications/Requirements
Ph.D. in pharmacology or relevant field with 6+ years of pharmaceutical/biotech industrial experience
Strong proficiency in fundamental aspects of small molecule oncology drug discovery and development programs
Experience with planning, design and execution of pre-clinical in vitro and in vivo studies including PK/PD, efficacy, ADME and toxicology
Significant experience in effectively managing CROs
Proven leadership capabilities in mentoring scientific staff and in forging collaborative partnerships with internal and external team members
Project leadership experience preferred
Excellent communication skills
Other Information
Alphina is proud to offer a competitive package of compensation and comprehensive benefits. Benefits include medical, dental and vision, retirement savings, life insurance and more.
Alphina Therapeutics is an Equal Opportunity employer. Alphina provides equal employment opportunities to all employees and applicants without regard to race (including hair texture and hairstyles), color, religious creed, sex, national origin, ancestry, pregnancy, childbirth, (or related medical conditions, including, but not limited to lactation), physical disability, mental and/or intellectual disability, age, military status or status as a Vietnam-era or special disabled veteran, marital status, registered domestic partner or civil union status, gender (including sex stereotyping and gender identity or expression), medical condition (including, but not limited to, cancer related or HIV/AIDS related), genetic information, or sexual orientation in accordance with applicable federal, state and local laws.
Alphina Therapeutics is considering only those applicants who have valid authorization to work in the United States of America. Alphina Therapeutics does not sponsor employment-based visas for this position.