Responsibilities • Develop and optimize methods to fully characterize oligonucleotide drug substance and drug
product materials, including HPLC, LCMS, ICP-MS, and all other relevant technologies. • Oversee and execute the characterization of oligonucleotide materials from discovery and research
stage through to development-stage compounds. • Collaborate with internal and external manufacturing partners to develop robust analytical
methods. • Report at project team meetings, write analytical development reports, provide recommendations
to management. • Manage and support junior team members and assist with recruiting efforts as needed. • Participate in multidisciplinary teams including Biology (in vitro and in vivo pharmacology), and
Chemistry (production, analytical sciences, and platform chemistry groups) • Provide periodic updates of efforts and results to senior management • Deliver innovative solutions using a diversity of thought and experiences. • Ensure the quality of each delivered entity. • Document all experimental activities and results in lab notebooks, report data with analysis of
results in presentations and/or written reports to the scientific team.
Required Qualifications • The level of this position will depend on education and experience qualifications:
o Principal Scientist - PhD in analytical, organic, or biochemistry with a minimum of 6
years industry experience and at least 4 years of direct oligonucleotide experience.
o Sr. Scientist - PhD in analytical, organic chemistry or a related discipline with a minimum
of 4 years industry experience and at least 2 years of direct oligonucleotide analysis
o Scientist - PhD in analytical, organic chemistry or a related discipline with a minimum of
1 year of direct experience in oligonucleotide analysis • Previous experience with oligonucleotide analytical methods within the biotechnology or
pharmaceutical industry setting is strongly preferred. • Strong method development skills including experience with HPLC/UPLC platforms, capillary
electrophoresis and mass spectrometry techniques is required • Previous experience with Orbitrap platform strongly preferred • Proficiency with Chromeleon, Xcalibur and Biopharma Finder is preferred. • Previous experience managing project teams or direct reports within a biotechnology organization is
preferred. • A history of authoring publications and/or study reports. • A deep commitment to working as part of teams to deliver breakthrough medicines. • Excellent communication, organization, and time management skills and ability to work both