Research Associate, Process Development at AstraZeneca in Santa Monica, California

Job Description:

Introduction to role:



Join our dynamic team at AstraZeneca as a Research Associate in Process Development. Based in Santa Monica, CA, you will be supporting and contributing to the design and execution of studies to develop and optimize clinical manufacturing processes of Neogene portfolio of engineered T cell therapies. This role reports to the Senior Scientist, Process Development.



Accountabilities:



As a Research Associate, you will manage process development studies to develop, optimize, scale-up and transfer cGMP manufacturing processes. You will carry out flow cytometry and cell-based assay experiments for the characterization of and optimization of cell therapy manufacturing processes. You will also perform cell culture of T cells in multiple formats including flasks, bags, and bioreactors. Collaborating within the project team to interpret study results and contribute to technical discussions for subsequent study design is also part of your role. You will prepare and review experimental proposals, technical reports, SOPs and manufacturing batch records. Working collaboratively within PD group and cross-functionally with other groups to meet Technical Operation organization goals is essential.



Essential Skills/Experience:



- A minimum of 6 months practical experience with Flow Cytometry


- Hands-on experience in primary cell culture, specifically in T cells is highly desirable


- Knowledge of cGMP manufacturing and regulations and practical experience in GMP operations is highly desirable


- Knowledge of statistical analysis for process development


- Ability to think critically, analytically and have demonstrated troubleshooting and problem-solving skills based on deductive reasoning


- MS degree in Immunology, Cell Biology, Molecular biology, Bioengineering, or relevant degrees or similar BS degree with 1.5+ years relevant experience within the pharmaceutical or biotech industries


When we put unexpected teams in the same room, we unleash bold thinking with the power to inspire life-changing medicines. In-person working gives us the platform we need to connect, work at pace and challenge perceptions. That's why we work, on average, a minimum of three days per week from the office. But that doesn't mean we're not flexible. We balance the expectation of being in the office while respecting individual flexibility. Join us in our unique and ambitious world.


At AstraZeneca, we are committed to leading the way in sustainability across our sites. We understand the critical role we play in helping to eliminate emissions from operations by 2025. Be part of fulfilling AstraZeneca's ambitious sustainability strategy by promoting sustainable work practices and spotting opportunities for improvement. We pioneer new approaches and processes across our sites, empowering our teams to foster a Lean mindset and sustainable practices. Every change we make is to deliver better outcomes for our patients.


Are you ready to be challenged in your everyday work? Do you have the drive and determination to overcome barriers and make things happen? If so, apply today and join us in making a difference!


The hourly rate of compensation for this position ranges from $34.23 to $51.35 per hour. Hourly and salaried non-exempt employees will also be paid overtime pay when working qualifying overtime hours. Base pay offered may vary depending on multiple individualized factors, including market location, job-related knowledge, skills, and experience. In addition, our positions offer a short-term incentive bonus opportunity; eligibility to participate in our equity-based long-term incentive program (salaried roles), to receive a retirement contribution (hourly roles), and commission payment eligibility (sales roles). Benefits offered included a qualified retirement program [401(k) plan]; paid vacation and holidays; paid leaves; and, health benefits including medical, prescription drug, dental, and vision coverage in accordance with the terms and conditions of the applicable plans. Additional details of participation in these benefit plans will be provided if an employee receives an offer of employment. If hired, employee will be in an "at-will position" and the Company reserves the right to modify base pay (as well as any other discretionary payment or compensation program) at any time, including for reasons related to individual performance, Company or individual department/team performance, and market factors.


AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements.