Scientist III, Medicinal Chemistry at AstraZeneca in New Haven, Connecticut

Job Description:

Are you a highly motivated, innovative, and data-driven Medicinal Chemist with broad drug discovery experience? Alexion Pharmaceuticals is looking for you! We have an exciting opportunity for a Scientist III position in Medicinal Chemistry at our vibrant New Haven research campus. You will join the small molecule research team and collaborate in the discovery of high-quality drug candidates. This role requires strong technical and problem-solving skills in Organic and Medicinal Chemistry, excellent communication, leadership, and organizational skills.


As a Scientist III, you will provide hands-on leadership in the design, synthesis, and characterization of molecules as part of drug discovery efforts. You will analyze screening data, perform literature reviews, design, propose, and implement medicinal chemistry plans. You will coordinate chemistry and biology data to support compound progression and patent strategies. You will contribute at all stages of a project, from inception, early project validation, optimization, candidate selection, and through to early development. You will work closely with other experts to identify key drug discovery issues, propose and implement creative solutions, execute on innovative medicinal chemistry designs, and guide teams to success and decision points. You will also contribute to the development of intellectual property and patent strategies.


Essential Skills/Experience:


- Ph.D. in synthetic organic or medicinal chemistry with 5-8 years of drug discovery experience in a pharmaceutical and/or biotechnology setting (may include post-doc experience)


- Contemporary knowledge of the key Medicinal Chemistry concepts and good understanding of biology, pharmacology, drug metabolism and pharmacokinetics


- A track-record of contributions to innovative drug discovery projects, exemplified by a record of patent inventorship, conference presentations and peer-reviewed publications


- Demonstrated identification and application of SAR toward successful hit-to-lead and lead compound optimization, and a proven track record of delivering clinical candidates


- Strong laboratory presence (60-70%) and experience mentoring scientists


- Outstanding communication skills


- Experience in structure-based drug design and computational chemistry


- Experience in hit identification techniques and progressing compounds from hit identification to clinical candidates


- Extensive track record of consistent and successful drug discovery accomplishments


- Supervise and direct synthetic chemistry activities at contract research organizations (CROs)


- Solid understanding of cellular/molecular biology, biochemistry, disease pharmacology, mechanisms of drug metabolism and molecular toxicology, pharmacokinetic and pharmacodynamic sciences, and formulations for the in vivo evaluation of drug candidates


When we put unexpected teams in the same room, we unleash bold thinking with the power to inspire life-changing medicines. In-person working gives us the platform we need to connect, work at pace and challenge perceptions. That's why we work, on average, a minimum of four days per week from the office. But that doesn't mean we're not flexible. We balance the expectation of being in the office while respecting individual flexibility. Join us in our unique and ambitious world.


Joining Alexion, AstraZeneca's Rare Disease division means embracing an opportunity where work isn't ordinary. In a company where 'Here it means more' is more than a statement, it's an ethos. We are a beacon in the global Biopharmaceutical landscape. Our closeness to patients brings us closer to our work and closer to each other. Combined with our brave, pioneering spirit - we are truly unique in R&D and healthcare. At Alexion, grow and innovate in a business with rapidly expanding portfolio.


Enjoy the vibe, entrepreneurial spirit and autonomy of a leading biotech. You'll join an energizing and kind culture where people build connections to explore new ideas and learn. As an important member of our commercial team, you'll be meeting the needs of some of the most under-served patients in the world. You will be empowered with tailored development programs designed not just for skill enhancement but for fostering a deep, empathetic understanding of our patient's journeys, aligning your growth with our mission. You're supported by a community of exceptional leaders and peers ready to lift you in marketing, compliance, and beyond.


Are you ready to make a difference where it truly counts? Join us at Alexion, where every day we change lives. Apply now!


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AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements.