Discovery Biotherapeutics is seeking a temporary, knowledgeable, self-motivated scientist to provide Antibody Drug Conjugate Bioconjugation and Chemistry support for the advancement of the ADC portfolio at company. The successful candidate must have strong chemistry and/or bioconjugation background as they will temporarily support discovery research and early process development activities for ongoing and new ADC projects.
Essential Duties and Responsibilities:
Conduct hands-on laboratories studies to support ADCs and bioconjugates.
Provides chemistry and bioconjugation expertise for state-of-the-art ADC technologies including linkers, payloads, novel conjugation methods, analytical assessments and testing and bring novel ideas to POC.
Assist in chemical synthesis discussion, planning and execution.
Critical scientific/technical data analysis, interpretation of experiments and report writing.
Effectively communicate scientific concepts, findings, and interpretation to multi-disciplinary teams.
Follows company intellectual property and compliance policies and practices.
Complies with company health and safety policies and general laboratory practices.
Education:
PhD in Chemistry or a closely related field and a minimum of three (3) years of related experience; or,
MS/MA in Chemistry or a closely related field and a minimum of seven (7) years of related experience; or,
BS/BA in Chemistry or a closely related field and a minimum of nine (9) years of related experience; or,
Equivalent combination of education and experience.
Experience:
Strong scientific understanding of chemistry, mechanism of action of cytotoxins and ADCs, and pharmacology studies in discovery of ADCs.
Hands on laboratory experience in bioconjugate research including critical reagent generation, identification, and optimization of bioconjugates, material production, purification, analytics, and characterization.
Experience in various aspects of small molecule chemical synthesis is preferred.
Demonstrated drive for rigorous scientific excellence. Ability to think critically and creatively to identify and solve scientific problems.
Knowledge/Skills/Abilities:
Knowledge of state of the art in different aspects of ADC research including conjugation technologies, linkers, and payloads.
Working knowledge of bioconjugation platforms, applications, and development.
Good working knowledge in analytical techniques including NMR, HPLC, and LCMS.
Ability to work independently, excellent time management and organization skills to manage multiple projects simultaneously.
Excellent written, oral, and interpersonal communication skills.
A strong team player.
Good tracking record and report writing.
Job Complexity:
Works on extremely complex problems where analysis of situations or data requires an evaluation of intangible variables.
Exercises independent judgment in developing methods, techniques, and evaluation criteria for obtaining results.
Uses professional concepts in accordance with company objectives to solve complex problems in creative and effective ways.