Scientist in vivo - Immunology at AstraZeneca in Gaithersburg, Maryland

Job Description:

The successful candidate will be a key member of an in vivo team within the Early Respiratory & Immunology in vivo Department, performing in vivo and ex vivo studies to support a diverse range of immunology-related projects. This role specifically involves working as a lab-based scientist in the area of in vivo pharmacology. As a strongly self-motivated and independent individual you will be adept at working across functional areas, enabling you to maximize value from the available resources. The role will sometimes involve implementing protocols over timelines that extend outside of normal working patterns.


Respiratory and Immunology is one of AstraZeneca's key therapeutic areas and our aim is to transform the lives of patients with chronic inflammatory and autoimmune diseases including atopic dermatitis, arthritis and lupus (SLE), as well as lung conditions such as asthma and COPD.


The successful candidate will assist with the design, execution and analysis of experiments to generate data in support of pipeline projects. You will be expected to utilize your expertise to run various in vivo disease models, as well as provide input for the establishment of new in vivo models.


This Scientist position entails initiating in vivo studies, preparing small and large molecules (and other modalities) for administration, daily dosing and in-life scoring/assessments, coordinating and performing necropsies for tissue collection, processing tissues and setting up ex vivo tests and experiments, analyzing/reporting data and conclusions to team members and project teams. You must demonstrate strong interpersonal skills and be able to work independently as well as part of a team.



Educational and Experience Requirements



A minimum of a BS and a minimum of 3 years direct experience. OR/


MS and a minimum of 1 year direct experience.


Significant lab-based in vivo experience and knowledge of ex vivo techniques for sample analysis (industry experience preferred)

• 
  Excellent hands-on rodent in vivo skills and the ability to independently run disease and mechanistic models, including administration of candidate drugs and collecting a range of biological samples.
  
  

• Ability to perform in vitro/ex vivo laboratory work: PBMC/cell isolation, tissue processing for single cell suspensions, 10+ multiparameter FACS staining, FlowJo analysis, multiplex ELISA, RNA isolation, qPCR/gene array, and handling human biological materials.
  
  

• A strong understanding of immune-mediated inflammatory diseases and experience with related in vivo techniques and model development for drug discovery projects.
  
  

• Experience of maintaining the highest standards of welfare and ethical compliance as well as ensuring the integrity of the data generated. Familiar with applying the 3Rs across the full range of studies.
  
  

• Able to independently assess and report data with a clear understanding of its reliability, interpret findings and draw appropriate conclusions.
  
  

• A thorough understanding of experimental design and applying the appropriate statistical methods.
  
  

• Excellent written and oral communication skills in English and able to proficiently use computers for data acquisition, processing, analysis and presentation
  
  

Why AstraZeneca?


At AstraZeneca when we see an opportunity for change, we seize it and make it happen, because any opportunity no matter how small, can be the start of something big. Delivering life-changing medicines is about being entrepreneurial - finding those moments and recognising their potential. Join us on our journey of building a new kind of organisation to reset expectations of what a bio-pharmaceutical company can be. This means we're opening new ways to work, pioneering cutting edge methods and bringing unexpected teams together. Interested? Come and join our journey.


The annual base pay (or hourly rate of compensation) for this position ranges from $87,200 to $130,800. Hourly and salaried non-exempt employees will also be paid overtime pay when working qualifying overtime hours. Base pay offered may vary depending on multiple individualized factors, including market location, job-related knowledge, skills, and experience. In addition, our positions offer a short-term incentive bonus opportunity; eligibility to participate in our equity-based long-term incentive program (salaried roles), to receive a retirement contribution (hourly roles), and commission payment eligibility (sales roles). Benefits offered included a qualified retirement program [401(k) plan]; paid vacation and holidays; paid leaves; and, health benefits including medical, prescription drug, dental, and vision coverage in accordance with the terms and conditions of the applicable plans. Additional details of participation in these benefit plans will be provided if an employee receives an offer of employment. If hired, employee will be in an "at-will position" and the Company reserves the right to modify base pay (as well as any other discretionary payment or compensation program) at any time, including for reasons related to individual performance, Company or individual department/team performance, and market factors.



So, what's next!


Are you ready to bring new ideas and fresh thinking to the table? Brilliant! We have one seat available and we hope it's yours.



Where can I find out more?


Our Social Media, Follow AstraZeneca on LinkedIn https://www.linkedin.com/company/1603/


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AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements. Apply Now