Senior Scientist, Next-Generation Conjugates at AstraZeneca in Gaithersburg, Maryland

Job Description:

Senior Scientist, Next-Generation Conjugates



As a Senior Scientist in Biologics Engineering and Tumor Targeted Delivery, Oncology R&D in Gaithersburg, MD, you'll play a pivotal role in channeling our scientific capabilities to make a positive impact on changing patients' lives! The Department of Biologics Engineering and Tumor Targeted Delivery is seeking a highly motivated scientist to further develop and implement AstraZeneca's proprietary non-natural amino acid platform for constructing next-generation protein conjugates. The successful candidate will contribute to the improvement of the transient expression system, development and support of new targeted therapy modalities entering AstraZeneca's pipeline, and expanding the capabilities of the nnAA chemistry to support high DAR therapeutics; i.e., branched linkers, dendrons, etc. A strong background in protein engineering and material science as well as competence in cell culture and protein purification is desired. The applicant will operate independently and in collaboration with team members and scientists across Research and Development to develop our next-generation conjugates platform. The selected individual will be a well-organized, productive bench scientist who can learn new procedures, design and execute experiments efficiently, work collaboratively, and analyze and interpret data.



Accountabilities

• Experience transiently expressing proteins


• Experience profiling targeted therapies in vitro


• Understanding of drug development, preferably biologics


• Experience with in vivo characterization preferred, i.e., mouse PK and TGI study design


• Strong interpersonal and communication skills as well as the ability to work within teams


• Familiarity with molecular biology is a plus


• Ability to multi-task and manage shifting priorities

Essential Skills/Experience

• PhD with 5 years of experience


• Strong understanding of non-natural amino acids and their use in targeted therapies


• Click-chemistry and thiol-maleimide conjugation experience


• Proficient in biophysical characterization of proteins (E.g., Biochemical assays, immunoassays, light scattering, and analytics)


• Cell culture and cell-based functional assays


• Ability to work collaboratively in a team environment


• Demonstrated experience in optimizing/troubleshooting protocols with a problem-solving mindset


• Excellent organizational skills, record keeping, and data presentation


• Track record of publications and/or presentations


• Familiarity with molecular biology techniques


• Experience with high DAR therapeutics such as branched linkers or dendrons

At AstraZeneca, we push the boundaries of science to change the practice of medicine and transform the lives of patients living with cancer. Our team is united by a vision to eliminate cancer as a cause of death. We make bold moves that transform cancer treatment and improve patient outcomes. With one of the broadest and deepest Oncology pipelines in the industry, there are many opportunities to work with new and novel drugs. We foster a mindset of courage, where everyone is empowered to innovate and work at pace. Our collaborative approach builds collective wisdom by giving everyone a chance to contribute.



Join us in our mission to make big paradigm shifts in treatment options. Apply today!



The annual base pay for this position ranges from $105,875.20 - 158,812.80. Hourly and salaried non-exempt employees will also be paid overtime pay when working qualifying overtime hours. Base pay offered may vary depending on multiple individualized factors, including market location, job-related knowledge, skills, and experience. In addition, our positions offer a short-term incentive bonus opportunity; eligibility to participate in our equity-based long-term incentive program (salaried roles), to receive a retirement contribution (hourly roles), and commission payment eligibility (sales roles). Benefits offered included a qualified retirement program [401(k) plan]; paid vacation and holidays; paid leaves; and, health benefits including medical, prescription drug, dental, and vision coverage in accordance with the terms and conditions of the applicable plans. Additional details of participation in these benefit plans will be provided if an employee receives an offer of employment. If hired, employee will be in an "at-will position" and the Company reserves the right to modify base pay (as well as any other discretionary payment or compensation program) at any time, including for reasons related to individual performance, Company or individual department/team performance, and market factors.


AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements. Apply Now