6-12mth contract (with long term contracting opportunity / potential future conversion)
Seeking a Scientist/Sr with background in molecular biology and protein biochemistry to work closely with members of the Antibody Discovery Team to support Large Molecule therapeutic programs.
RESPONSIBILITIES
Design strategies and execute antibody discovery campaigns for therapeutic and reagent antibodies using phage display
Generate antibody fragment libraries for antibody discovery and engineering, perform HT binding screens (ELISA and multi-plex flow cytometry) and sequence analysis to generate hits
Rank-order clones by affinity, in vitro potency, and early developability assessment
Execute sequence optimization of lead antibodies to improve developability and binding affinity
Design and clone constructs for mAbs, bispecific, and multi-specific antibodies for recombinant antibody production
Support NGS-based antibody discovery workflow
Present data and updates to management and project teams
Follow good documentation practice including maintaining good record keeping in Electronic Notebooks
REQUIRED QUALIFICATIONS AND BACKGROUND
PhD in Biochemistry, Biomedical/Chemical Engineering, Immunology, or related field with minimum of 2 years of post-graduate experience (preferably in industry), MS with 8+ years of research experience, BS with 10+ years of research experience in antibody or protein engineering
Significant experience in antibody discovery and protein engineering by using single B cell cloning, hybridoma, or phage/yeast display techniques
Strong background in molecular biology, antibody and protein expression, and biophysical characterization of recombinant antibodies and proteins
ADDITIONAL PREFERENCES
Experience in single domain antibodies, multi-specific antibody engineering, Fc engineering, antibody drug conjugates, naïve phage or yeast display library design
Experience in NGS analysis for antibody discovery and engineering
Significant contributions to successful biologics drug discovery programs in industry