Akkodis is seeking an Scientist for a 12-month contract position with a global healthcare and pharmaceutical client in Cambridge, MA.
Pay Rate: $49.00/hour to $65.00/ hour
Onsite: Cambridge, MA
This is NOT an IT or Software position.
Our Client is seeking a highly motivated Scientist I or Scientist II to join the Non-Viral Gene Therapy (NVGT) Team. The successful candidate will have hands-on experience in antibody and protein engineering, with a focus on bioconjugation chemistry. The candidate will work closely with the LNP formulation team to achieve extrahepatic delivery of LNPs.
Open to candidates willing to relocate at their own expense.
Paid parking required
Must Have: • PhD in Chemistry, Biology, Biological Engineering, or a related field • Min 1 year of professional work experience (in biotech or pharma) • Protein and antibody engineering workflows, including primary sequence design, expression, purification, characterization • Bioconjugate chemistry, also referred to as: antibody conjugate experience ADJ • Strong analytical bio chem skills • SDS page, chromatography, HPLC
Preferred Skills: • Previous experience with: (liquid handler, automated buffers) - biochemical assays (nice to have) • Computational skills • Computational and AI/ML approaches for rational protein engineering, including AI 3D structure prediction, homology modeling, antibody/antigen docking, other relevant experience • L&P Experience
Responsibilities: • Execute protein conjugation reactions for both screening efforts and developability to enable nanoparticle targeting to specific cells and/or tissues. • Perform downstream analytical assays such as SDS-PAGE, SEC-HPLC, RP-HPLC, BLI, DSF, CE-SDS and/or flow-cytometry. • Perform incorporation of targeting antibody into LNPs and execute associated analytical assays, including DLS, zeta potential, nucleic acid content, endotoxin • Design protein and antibody molecules at the primary sequence level • Support management of CRO for molecule production • Closely work with therapeutic area biologists and project teams to design functional experiments and interpret data • Execute and carefully document experiments using electronic laboratory notebook system and clearly communicate results to team members. • Plan, execute, and record experiments as guided in a time sensitive manner. • Assume responsibility for critical reagent sourcing and maintain adequate supply and inventory. • Author standard operating procedures, study plans and reports and present findings. • Foster creativity, productivity, execution with a sense of urgency, scientific integrity and accountability. Maintains a collaborative culture.
Requirements: • PhD in Chemistry, Biology, Biological Engineering, or a related field with a minimum of 1-3 years of relevant industry experience. • Strong experience with protein and antibody engineering workflows, including primary sequence design, expression, purification, characterization • Direct experience with site-specific bioconjugate chemistry • Strong analytical biochemistry experience for protein and antibody engineering • Proficient in performing structure-function analysis and bioinformatic analysis of antibodies, antigens, and other proteins • Experience with automation and high throughput platform(s) • Experience with Biolayer Interferometry or equivalent technique • Preferred use of computational and AI/ML approaches for rational protein engineering, including AI 3D structure prediction, homology modeling, antibody/antigen docking, other relevant experience • Preferred familiarity with formulation and analysis of lipid nanoparticles for research use • Outstanding written and oral communication skills along with the ability to work collaboratively in a team setting. • Demonstrated knowledge and skills in solving scientific problems, ability to troubleshoot, and willingness to learn. • Demonstrated ability to independently design, execute, interpret, and present experimental results. • Flexibility to adapt to rapidly changing priorities and deadlines in a dynamic, fast paced industry and work environment.
If you are interested in this Onsite Scientist job in Cambridge, MA please click APPLY NOW. For other opportunities available at Akkodis go to www.akkodis.com.
Equal Opportunity Employer/Veterans/Disabled
Benefit offerings include medical, dental, vision, term life insurance, short-term disability insurance, additional voluntary benefits, commuter benefits and 401K plan. Our program provides employees the flexibility to choose the type of coverage that meets their individual needs. Available paid leave may include Paid Sick Leave, where required by law; any other paid leave required by Federal, State or local law; and Holiday pay upon meeting eligibility criteria. Disclaimer: These benefit offerings do not apply to client-recruited jobs and jobs which are direct hire to a client
To read our Candidate Privacy Information Statement, which explains how we will use your information, please visit https://www.modis.com/en-us/candidate-privacy/