Senior Scientist (Hematology Oncology) at AstraZeneca in Waltham, Massachusetts

Job Description:

Senior Scientist (Hematology Oncology)




Introduction to role:



We are seeking a highly motivated Senior Scientist in cancer pharmacology with a track record of scientific excellence to join our team in Waltham, MA. As a Senior Scientist, you will be leading from the bench and a member of the in vivo team focused on delivering in vivo pharmacology datasets that will have a direct impact on the drug discovery pipeline. Are you ready to make a difference in the fight against cancer?



Accountabilities:

• Use in vivo technical skills to support oncology drug discovery by:
  
  
  
  
  • Developing and working with various in vivo models of cancer including subcutaneous and disseminated cell line and patient-derived xenograft models
    
    
  
  
  • Delivering tolerability, PKPD, and efficacy studies to build comprehensive in vivo pharmacology data packages to support drug discovery programs
    
    
  
  
  • Profiling tissue samples to explore mechanisms of drug response using both traditional and novel approaches
    
    
  
  
  
  


• Work with various software programs and databases to capture all study data
  
  


• Work collaboratively across project teams and disciplines to advance projects
  
  


• Independently provide data analysis and interpretation
  
  


• Present in relevant meetings to project teams and stakeholders
  
  


• Manage timelines for study delivery
  
  


• Propose novel technologies and approaches to improve or replace existing disease model platforms
  
  

Essential Skills/Experience:

• PhD with 2+ years' experience in biology, pharmacology, or related field
  
  


• Demonstrated experience generating and working hands-on with various rodent disease models
  
  


• Understanding of pharmacology concepts such as pharmacodynamics and pharmacokinetics
  
  


• Experience and knowledge of oncology
  
  


• Ability to develop and deliver clear presentations and effectively communicate key messages
  
  


• Ability to work both independently and within multidisciplinary project teams
  
  


• Strong organizational skills
  
  


• Experience using molecular and cell biology techniques such as Western blot, RT-PCR, flow cytometry, and ELISA/MSD
  
  


• Understanding of statistical methods and their applications
  
  


• Familiarity with software programs include GraphPad Prism, Microsoft Office suite, and in vivo data capture systems (e.g. Study Log or similar)
  
  

Desirable Skills/Experience:

• Prior experience in biotech or pharma
  
  


• Experience delivering all aspects of PKPD, efficacy, and tolerability studies in xenograft models
  
  


• Experience working with disseminated hematologic cancer models
  
  


• Experience with flow cytometry, including ability to design panels, profile markers in tissue using MACSQuant and/or BD cytometers, and analyze data in FlowJo
  
  


• Experience using small animal imaging modalities (e.g. Xenogen, ultrasound)
  
  

When we put unexpected teams in the same room, we unleash bold thinking with the power to inspire life-changing medicines. In-person working gives us the platform we need to connect, work at pace and challenge perceptions. That's why we work, on average, a minimum of three days per week from the office. But that doesn't mean we're not flexible. We balance the expectation of being in the office while respecting individual flexibility. Join us in our unique and ambitious world.


Join the team at the heart of AstraZeneca that is committed and encouraged to follow the science. Driven by our curiosity, passion, and determination we are paving the way to change the practice of medicine in Oncology. Ready to make a difference? Apply today!


AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements. Apply Now