Biologics - Upstream Cell Line Development at Eurofins Lancaster Laboratories Professional Scientific Services, LLC in Cambridge, Massachusetts
Posted in Other about 4 hours ago.
Job Description:
Biologics - Upstream Cell Line Development
Employee Responsibilities include, but are not limited to:
- Support the cell line development (CLD) team through participation in transfection, stable selection, cloning, expansion and characterization of mammalian cell lines for clinical and commercial production
- Perform laboratory experiments using a variety of CLD and cell culture technologies including single cell cloning/clone picking, cell imaging, liquid handling automation and Octet/ELISA-based recombinant protein quantification
- Support molecular characterization of the lead clonal cell lines for CLD programs including but not limited to mRNA analysis and gene copy number determination
- Works with departmental and/or cross functional peers to execute on assignments, under limited supervision.
- Prepares experimental protocols.
- Contributes significantly to project work which may include multiple projects within functional area.
- Interprets data independently, and contributes to technical reports
- Identifies technical issues, and implements solutions under supervision
- Contributes to the design of new applications/experiments/unit operations in consultation with supervisor.
- Coordinates within department as well as cross functionally with peers on projects.
- Experience in CLD technologies including culture of mammalian cells, single-cell cloning (sorting/clone picking), clonality assessment, and clone screening highly desirable
- Experience in molecular biology methods including subcloning, RT-qPCR/ddPCR and Octet/ELISA-based recombinant protein quantification is desirable
- Experience with FACS, automation or Next-Gen Sequencing will be a plus.
- Familiar with general laboratory procedures and aseptic technique.
- Able to troubleshoot critical issues or problems and resolve routine issues using appropriate information.
- Ability to work within department groups/team.
- Exercises good time management skills
- Proficiency in use of applicable lab equipment and operations; experience in maintaining written records of work in the form of laboratory notebooks (paper or electronic)
- Expresses one's self clearly and concisely within function; documents issues and/or concerns concisely with colleagues; timely and effectively communicates issues to supervisor
- Bachelor's degree in biochemistry, biology, biotechnology, or related pharmaceutical science; 4+ years of biotechnology/biopharmaceutical industry experience in cell line development OR
- Master's degree in biochemistry, biology, biotechnology, or related pharmaceutical science; 1+ year of biotechnology/biopharmaceutical industry experience in cell line development
- Sound knowledge of cell culture principles, experience in aseptic techniques required
- Computer experience in common Microsoft applications (Word, Excel, PowerPoint) is required
- Excellent full time benefits including comprehensive medical coverage, dental, and vision options
- Life and disability insurance
- 401(k) with company match
- Paid vacation and holidays
Eurofins Lancaster Laboratories Professional Scientific Services ® (PSS) is a global, award-winning insourcing solution that places our people at our clients' site dedicated to running and managing laboratory services while eliminating headcount, co-employment and project-management worries.
We infuse our 55-year track record of scientific and laboratory operations expertise, as well as HR and great place to work best practices, to recruit, hire, train and manage highly qualified scientists to perform laboratory services using our client's quality systems and equipment.
Eurofins is a M/F, Disabled, and Veteran Equal Employment Opportunity and Affirmative Action employer.
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