Senior Scientist, Biochemical Assay Development at Eurofins Lancaster Laboratories Professional Scientific Services, LLC in Boston, Massachusetts

Job Description:

Sr. Scientist, Biochemical Assay Development




Employee Responsibilities:


This position will involve performing biochemical assay development for HTS/MTS campaigns; to support med chemistry effort and test potency of research compounds (SAR, MOA, etc.)


The Ideal Candidate would possess:

• Experience successfully carrying out basic lab operation (buffer preparation/characterization; solutions, sample preparation, dilution, basic instrument troubleshooting and problem solving so to minimize equipment downtime).
• Biochemical assay development and execution : Develop high quality, robust biochemical assays for MTS/HTS campaigns; the potency and MOA testing of small molecules to support drug discovery
  • Determine kinetic characteristics of an enzyme activity including Km, linearity, stability, tolerability, etc.
  • Complete the development successfully
    • Achieve a robust enzyme response with compliance to NIH guidelines
    • Perform HML and IC50 tests
  • Timely record critical experimental findings and communicate back to the team and med chemistry group
  • Achieve turnaround time for compound testing within 24-48 hours
  • Make sound judgment on scientific merits and seek advice when appropriate
• LC/MS methods: Carry out biochemical assays using LC/MS technology
  • Develop successful LC/MS method for detection of analyte of interest (collaboration with Analytical R&D, Waltham)
  • Prepare calibration curves
  • Achieve desired assay window
    • Minimize background and carryover signals
  • Timely record all experimental findings in adequate details in eLN
  • Seek advice when appropriate

Minimum Qualifications:

• B.S. with 4-6 years of related experience or M.S. with 2-3 years of related experience


• Authorization to work in the United States indefinitely without restriction or sponsorship

What we offer:

• Excellent full time benefits including comprehensive medical coverage, dental, and vision options


• Life and disability insurance


• 401(k) with company match


• Paid vacation and holidays

Candidates currently living within a commutable distance of site are encouraged to apply.

Eurofins Lancaster Laboratories Professional Scientific Services ® (PSS) is a global, award-winning insourcing solution that places our people at our clients' site dedicated to running and managing laboratory services while eliminating headcount, co-employment and project-management worries.

We infuse our 55-year track record of scientific and laboratory operations expertise, as well as HR and great place to work best practices, to recruit, hire, train and manage highly qualified scientists to perform laboratory services using our client's quality systems and equipment.

Eurofins is a M/F, Disabled, and Veteran Equal Employment Opportunity and Affirmative Action employer.


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