Research Associate - Neuroscience and Pharmacology (Tomchik Lab) - Stem Cell Research at University of Iowa in Iowa City, Iowa

Job Description:

The Carver College of Medicine Department of Neuroscience and Pharmacology (Dr. Tomchik lab) is seeking a Research Associate. This Research Associate will carry out research on the mechanisms of mechanisms of neuronal dysfunction in neurofibromatosis type 1. A major aim of our research uses cell culture models to examine how mutations in the neurofibromin 1 (NF1) gene affect function of neurons and other cell types. We have recently discovered that mutations in the NF1 gene affect behavior and metabolism in a Drosophila model of neurofibromatosis type 1 (Botero et al., 2021, Nature Communications 12(1): 4285; Omana Suarez et al., 2024, bioRxiv doi:10.1101/2024.08.08.607070). We are currently diving into the molecular, cellular, and circuit mechanisms using cell culture models. This position provides training in state-of-the-art cell culture approaches and the opportunity to join a dynamic, supportive lab, as well as outstanding collaborators. This position would be ideal for someone with a bachelor's degree plus 1-3+ years of full-time research experience.

Duties will include (but are not limited to) the following:

• Carry out a variety of experiments with minimal oversight, seeking guidance when needed.
• Maintain human induced pluoripotent stem cell lines. Differentiate iPSCs into neurons and other cell types. Carry out morphological experiments using immunohistochemistry and microscopy for various markers.
• Conduct neuroscience- and metabolic-focused analyses, working both independently and working with core facilities.
• Perform experiments independently based on protocols developed by other research staff or principal investigator of the research project.
• Set up and operate research materials/equipment. Perform procedures assuring fidelity to protocols.
• Arrange and plan daily activities to prepare and carry out experiments to meet overall research goals. Track progress of research, identify any failure points, troubleshoot, consult with others when necessary/helpful, and ensure continued progress of research to meet goals.
• Read and review research articles to develop knowledge of the research area. As knowledge/skills develop, analyze literature to develop hypotheses for discussion with other researchers and the principal investigator.
• Adhere to safety and regulatory guidelines. Assist with ensuring that the working environment and records/documentation are compliant with applicable health and safety regulations. Collate documentation for protocol submissions (IBC, etc.) as requested.
• Keep detailed records of experiments. Present research results verbally at lab meetings. Prepare written research results for publication. Present research results at research conferences, locally and nationally.
• Order and maintain records of drugs/chemical agents and other supplies. Assist in the maintenance of lab equipment, monitoring lab inventory, arranging service contracts, and interfacing with technicians and vendors.
• Assist graduate students and postdocs with experiments as requested by the principal investigator.

Percent of Time: 100%


Staff Type: Professional & Scientific


Type of Position: Specified Term. Initial appointment is for one year. Appointment may be extended based on performance and availability of funding.


Pay Grade: 4A - https://hr.uiowa.edu/professional-pay/compensation-plan-structure-a-FY18



Benefits Highlights

• Regular salaried position located in Iowa City, Iowa
• Fringe benefit package including paid vacation; sick leave; health, dental, life and disability insurance options; and generous employer contributions into retirement plans
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Required Qualifications:

• Requires a bachelor's degree in a biomedical related field, other related science program, or equivalent combination of education and progressively responsible experience in a research laboratory environment
• A minimum of 1-3 years of progressively responsible experience in a relevant research laboratory environment
• Ability to work independently while being accountable and efficient with time management
• Demonstrated ability to maintain a highly-organized, consistent, systematic, and detail-oriented approach
• Excellent written and verbal communication skills, organizational skills, and interpersonal skills
• Basic histology techniques (e.g., immunohistochemistry)
• Experience with DNA techniques: DNA isolation, PCR, and/or qPCR

Desirable Qualifications:

• Experience with cell culture models
• Experience with biochemistry approaches (e.g., western blots)
• Microscopy experience
• Familiarity with Graphpad Prism and/or Adobe Illustrator

Application Process: In order to be considered, applicants must upload a CV or resume, and cover letter (under submission relevant materials) that clearly address how they meet the listed required and desired qualifications of this position.


Job openings are posted for a minimum of 14 calendar days and may be removed from posting and filled any time after the original posting period has ended. Successful candidates will be required to self-disclose any conviction history and will be subject to a criminal background check and credential/education verification. Up to 5 professional references will be requested at a later step in the recruitment process.


The department intends to hire for one position from either Research Assistant, requisition 24006011 or Research Associate, requisition 24006013 based on the qualifications of the successful candidate. Please apply to the specific position for which you wish to be considered.


For additional questions, please contact Anne Beyerink at anne-phillips@uiowa.edu.


Additional Information

• Classification Title: Research Associate
• Appointment Type: Professional and Scientific
• Schedule: Full-time

Compensation

• Pay Level: 4A

Contact Information

• Organization: Healthcare
• Contact Name: Anne Beyerink
• Contact Email: anne-phillips@uiowa.edu

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