Research Lab Tech 1 (Chekuri) at Partner's Healthcare in Boston, Massachusetts

Job Description:

Site: Massachusetts Eye and Ear Infirmary


At Mass General Brigham, we know it takes a surprising range of talented professionals to advance our mission-from doctors, nurses, business people and tech experts, to dedicated researchers and systems analysts. As a not-for-profit organization, Mass General Brigham is committed to supporting patient care, research, teaching, and service to the community. We place great value on being a diverse, equitable and inclusive organization as we aim to reflect the diversity of the patients we serve.


At Mass General Brigham, we believe a diverse set of backgrounds and lived experiences makes us stronger by challenging our assumptions with new perspectives that can drive revolutionary discoveries in medical innovations in research and patient care. Therefore, we invite and welcome applicants from traditionally underrepresented groups in healthcare - people of color, people with disabilities, LGBTQ community, and/or gender expansive, first and second-generation immigrants, veterans, and people from different socioeconomic backgrounds - to apply.



Job Summary
POSITION SUMMARY: The Grousbeck Gene Therapy Center at Mass Eye and Ear has an open position for a Research Assistant to assist in the application of novel gene therapy modalities. The Center provides a dynamic multi-disciplinary environment that pursues the common goal of developing therapeutic gene transfer in future medicine. We are seeking a Research Assistant to join the laboratory of Dr. Anil Chekuri to perform in vivo experiments both in small animal models. The main responsibilities of this position will include animal experimentation and rodent colony management. Familiarity with tissue processing is desirable. Demonstrated excellence in time management and organizational skills are essential. A bachelor's degree in biology or related discipline is required. We offer a flexible and collaborative environment, as well as the opportunity to develop scientifically and explore the promising field of translational AAV gene therapy. ESSENTIAL FUNCTIONS: • Animal work (rodents): - Colony management and animal handling (breeding, tagging, and genotyping) - Sub-retinal injections - Injections (SQ, IM, RO, IV, IVT, SR, IP) - In vivo imaging and Electroretinography - Pre-op and post-op care - Euthanasia/necropsy - Tissue collection • Ensure cleanliness of the lab and equipment including instrument maintenance. • Adherence to pertinent departmental policies, practices and procedures (SOPs, IACUC, Hazardous materials, safety procedures and biosafety protocols). • Keep accurate records of experiments; analyze data, and present results to PI. • Tissue processing (tissue fixation/freezing, embedding, cryo-sectioning and DNA/RNA extraction) is an asset. • Molecular cloning of plasmids using PCR, restriction digestion and other methods • Cell and tissue culture. • Biochemical assays including SDS-PAGE and ELISA.



Qualifications


EDUCATION AND EXPERIENCE: - BS/BA in biology preferred or related discipline - Experience in or willing to learn vivo rodent manipulation (including colony management, injections and necropsies). - Experience in or willing to learn Optical coherence tomography, fundus imaging, and in vivo bioluminescence imaging. - Must be able to work as part of a team. - Excellent time management and organization. WORKING CONDITIONS: Work will primarily take place in a research laboratory setting. Job may require exposure to bio-hazardous or toxic substances. PHYSICAL REQUIREMENTS: Position requires alertness and manual dexterity.



Additional Job Details (if applicable)


Additional Job Description



Remote Type


Hybrid



Work Location


20 Staniford Street



Scheduled Weekly Hours


40



Employee Type


Regular



Work Shift


Day (United States of America)



EEO Statement:


Massachusetts Eye and Ear Infirmary is an Affirmative Action Employer. By embracing diverse skills, perspectives and ideas, we choose to lead. All qualified applicants will receive consideration for employment without regard to race, color, religious creed, national origin, sex, age, gender identity, disability, sexual orientation, military service, genetic information, and/or other status protected under law. We will ensure that all individuals with a disability are provided a reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment.



Mass General Brigham Competency Framework


At Mass General Brigham, our competency framework defines what effective leadership "looks like" by specifying which behaviors are most critical for successful performance at each job level. The framework is comprised of ten competencies (half People-Focused, half Performance-Focused) and are defined by observable and measurable skills and behaviors that contribute to workplace effectiveness and career success. These competencies are used to evaluate performance, make hiring decisions, identify development needs, mobilize employees across our system, and establish a strong talent pipeline.