This is a Bio-conjugation Scientist role with MRL SSF Discovery Chemistry group.
*** is currently seeking highly motivated and exceptional a Bio-conjugation Scientist for position within the Discovery Chemistry Department located at our South San Francisco, CA site. • The successful candidate will join multidisciplinary, highly collaborative discovery teams to invent Client medicines by applying optimized conjugation protocols, analytical techniques, and data analysis to synthesize drug candidates and intermediates. • Successful candidates must have excellent interpersonal, collaboration, and communication skills in a team environment. • Additionally, it is expected that the successful candidate will learn quickly through on-the-job training to become increasingly skilled and independent in reaction setup, route design and optimization.
Specific responsibilities will include: • Perform bioconjugations of linker-payload combinations to antibodies with emphasis on in-house established methods • Selection and application of appropriate purification techniques for biologics (i.e., SEC, hydrophobic interaction chromatography, ion exchange chromatography) • Acquisition and interpretation of analytical data such as LC/MS.
Qualifications:
Education Requirement: • Minimum qualifications include a B.S./M.S/ PHD in chemistry, biochemistry, or related field, with industrial or academic experience.
Experience and Skills Required: • Hands on experience with conjugation, purification and characterization of antibody drug conjugates, and experience using analytical techniques/instrumentation, including chromatographic techniques such as HIC (Hydrophobic Interaction Chromatography) and RP (Reverse Phase), SEC, SDS-PAGE, UV?Vis.
• Nice to have skills: Biologics analytic experience, purification techniques.
• Must have: Bio-conjugation experience, protein biochemistry and Chemistry background.
• Personality: Team player, Adheres to timeline, Communicative and collaborative.
Note: Onsite, 100% Lab based role. Possibility of extension.