At Pattern Biosciences, we build DNA computers that run molecular programs in cells to treat cancer and other diseases. Using multi-input molecular-level computation in individual cells, our approach leads to curative therapies where the conventional one drug-one target paradigm has failed to deliver effective treatments. We are building a world-class team at our headquarters in South San Francisco to translate two decades of scientific progress in DNA computing and synthetic biology into the clinic.
About the role
You will design and execute in vivo studies of AAV-based cancer therapeutic candidates to advance our oncology pipeline and technology platform. You will contribute to study design and lead their execution, ensuring high level of scientific rigor and compliance with relevant regulations. This is an ideal position for a candidate with a strong background in in vivo experiments who thrives in a team-oriented, cross-disciplinary, and collaborative environment.
Key responsibilities
Plan and execute preclinical in vivo studies in murine tumor models in collaboration with discovery scientists.
Perform hands-on in vivo experiments, including orthotopic tumor cell implantation using abdominal surgery, intravenous (IV), intraperitoneal (IP), and subcutaneous (SC) injections, in vivo imaging, and animal health monitoring.
Perform necropsy, tissue collection and processing (e.g. FFPE and OCT), tissue dissociation and downstream assays such as cell sorting, flow cytometry and immune assays, etc., to characterize the mechanism of action and assess efficacy and safety of therapeutic candidates.
Generate, document, and analyze in vivo study data in accordance with study protocols, SOPs, and regulatory guidelines.
Interface with external laboratories and partners.
Who you are
MSc or PhD in Life Sciences.
At least 3 years of hands-on experience working with murine tumor models in an academic or industry setting.
Demonstrated experience in in vivo procedures, such as rodent surgery, IV dosing, and blood sampling
Experience in tissue processing, cell sorting, and immune functional assays. Experience in immune cell and cytokine profiling is a plus.
Detail-oriented with strong organizational and record-keeping skills.
Excellent communication skills and ability to collaborate effectively in a cross-functional team.
Experience working in a GLP or regulatory-compliant environment is a plus.
To apply, please submit a cover letter and a detailed CV to careers@patternbio.com