Sr. Scientist - Genome Editing, Discovery and Validation at Alkermes, Inc. in Waltham, Massachusetts

Job Description:

We are seeking an enthusiastic and highly motivated Sr. Scientist to join the Functional Genomics team within Alkermes R&D, focusing on the application of CRISPR-based technologies to validate therapeutic hypotheses in vitro and in vivo for central nervous system (CNS) disorders.

Responsibilities

• Design, develop, and execute CRISPR-based functional genomics strategies to validate therapeutic hypotheses in vitro and in preclinical models of CNS diseases.


• Utilize CRISPR/Cas9, CRISPRa, and CRISPRi approaches to modulate gene expression and investigate target biology in the context of neuroanatomy and neurocircuitry.


• Develop and optimize CRISPR delivery methodologies, including viral and non-viral delivery systems, for precise gene editing in the CNS.


• Establish and validate CRISPR-edited rodent models using molecular, cellular, and behavioral readouts to assess target engagement and functional outcomes.


• Collaborate cross-functionally with neuroscience, pharmacology, and translational teams to integrate functional genomics insights into drug discovery programs.


• Perform molecular and cellular assays, including PCR, NGS, immunohistochemistry, and single-cell sequencing, to confirm CRISPR-mediated gene modifications.


• Maintain detailed records of experimental design, execution, and data interpretation in accordance with corporate documentation standards.


• Keep abreast of emerging CRISPR technologies and functional genomics advancements to drive innovation within the team.


• Effectively communicate findings and recommendations to internal and external stakeholders.

Qualifications

• Ph.D. in Neuroscience, Molecular Biology, Genomics, or a related field with a minimum of 3 years of relevant experience, preferably in CNS disorders.


• Expertise in CRISPR-based gene editing techniques, including CRISPR/Cas9, CRISPRa, and CRISPRi.


• Experience with in vivo CRISPR delivery methods such as AAV, lipid nanoparticles, or electroporation for targeting CNS circuits.


• Strong background in neuroanatomy and neurocircuitry, with experience in functional validation of gene edits in preclinical models.


• Proficiency in standard molecular biology and tissue culture techniques, including developing and maintaining CRISPR-edited cell lines.


• Familiarity with in vivo rodent models, behavioral assays, and CNS-relevant phenotypic assessments.


• Proficiency with computational tools (Python, R, or Unix CLI) for analyzing CRISPR screening data.


• Strong data analysis and interpretation skills, with experience using bioinformatics tools for genomic analysis.


• Excellent communication and collaboration skills in a cross-disciplinary research environment.

Preferred Qualifications:

• Experience with single-cell RNA sequencing, spatial transcriptomics, or electrophysiological techniques to assess gene function in CNS models.


• Prior industry experience in functional genomics or CNS drug discovery is a plus.

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  About Us

  
  

  Why join Team Alkermes?

  
  

  Alkermes applies its deep neuroscience expertise to develop medicines designed to help people living with complex and difficult-to-treat psychiatric and neurological disorders. A fully-integrated, global biopharmaceutical company, headquartered in Ireland with U.S. locations in Massachusetts and Ohio, we are committed to pursuing great science, driven by deep compassion to make a real impact in the lives of patients. Alkermes has a portfolio of proprietary commercial products for the treatment of alcohol dependence, opioid dependence, schizophrenia and bipolar I disorder, and a pipeline of clinical and preclinical candidates in development for various neurological disorders, including narcolepsy.

  
  
  
  

  Beyond our important mission of developing medicines to address unmet patient needs, we actively seek to foster a culture of diversity, inclusion and belonging throughout our business. We strive to ensure that all voices are respected and valued, recognizing that our diversity of thought, background and perspective makes us stronger. We are proud to have been recognized as an employer of choice by many national organizations, including being certified as a Great Place to Work in the U.S. in 2024, honored as a Healthiest Employer in both Ohio and Massachusetts in 2023, a Best Place for Working Parents in 2023, and to have received the Bell Seal at the Platinum level for Workplace Mental Health by Mental Health America for three consecutive years (2021-2023).

  
  
  
  

  Alkermes, Inc. is an equal employment opportunity employer and does not discriminate against any qualified applicant or employee because of race, creed, color, age, national origin, ancestry, religion, gender, sexual orientation, gender expression and identity, disability, genetic information, veteran status, military status, application for military service or any other characteristic protected by local, state or federal law. Alkermes also complies with all work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Alkermes is an E-Verify employer.

  
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