Postdoctoral Fellow Meselson Lab at Harvard University in Cambridge, Massachusetts

Job Description:

Harvard University


Title: Postdoctoral Fellow Meselson Lab

School: Faculty of Arts and Sciences

Department_Area: Molecular and Cellular Biology

Position Description: Postdoc Position in Bioinformatics, Evolutionary Biology

Matthew Meselson (Professor of Biology, Harvard), in collaboration with Tim Sackton (Director of Bioinformatics, Harvard FAS ), has an opening for a postdoctoral position to use long-read technology (Nanopore, PacBio, 10x) to better understand the unique biology of bdelloid rotifers. The position is available immediately. Start date is flexible.

The great majority of eukaryotes reproduce sexually, either constitutively or facultatively, and nearly all that are thought to be entirely asexual diverged only recently from sexual relatives, suggesting that the loss of sex leads to early extinction. Posing a challenge to this generalization and to hypotheses for the evolutionary benefit of sex are a few groups of ancient origin in which, despite considerable study, sexual reproduction has never been observed - the so-called ancient asexuals. The most extensively studied of these are the rotifers of Class Bdelloidea. Although certainly ancient, evidence for their asexuality is entirely negative - the failure, despite much observation, to find males. Using 10x and nanopore sequencing to obtain phased genomic sequences of individuals of the bdelloid rotifer Macrotrachela quadricornifera , the project would conduct a critical test of recent population-genetic evidence that bdelloids occasionally do reproduce sexually, perhaps with meiosis of an atypical sort - a situation possibly adapted to the unusual bdelloid life history (Signorovitch et al . 2015. Genetics 200: 581-590).

Basic Qualifications: Candidates must be proficient in advanced bioinformatic methods of sequence assembly and analysis. Doctoral degree in bioinformatics, evolutionary biology, or related field. Prior experience with analysis of genetic sequences required. Strong communication skills including scientific reading and writing in English necessary,


Special Instructions: Letters of recommendation are required at the time of application. Candidates should submit with their application contact information for two to three references from experts at the ladder faculty ranks or highly accomplished senior researchers from corporations or research institutes.

Please include the following items as part of your application:

• Cover letter briefly describing your research experiences, skills, interests, and future plan
• CV with full publication list
• Name and contact information for 2-3 references.

Contact Information: Professor Matthew Meselson
Biological Lab
16 Divinity Avenue
Cambridge, MA 02138

Camila Ossa (Administrator)
camila_ossa@harvard.edu

Contact Email: jmontgom@mcb.harvard.edu

Equal Opportunity Employer: We are an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, disability status, protected veteran status, gender identity, sexual orientation, pregnancy and pregnancy-related conditions or any other characteristic protected by law.

Minimum Number of References Required: 2

Maximum Number of References Allowed: 3


Supplemental Questions: Required fields are indicated with an asterisk (*).



Equal employment opportunity, including veterans and individuals with disabilities.

PI267979710

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