The successful candidate will be responsible for non-regulated quantitative LC-MS/MS bioanalysis of small molecules from in vivo and in vitro samples, including extraction, data analysis and interpretation.
Responsibilities: • Use liquid handling robotics. • Perform quantitative LC-MS/MS (Liquid Chromatography Mass Spectrometry) analysis of small molecules from various bio-matrices in vivo and in vitro to support PK/PD, ADME, efficacy, and exploratory toxicology studies. • Basic Operation and troubleshooting of AB Sciex LC-MS/MS systems. • Maintain excellent documentation of all work including LIMS, test methods, and protocols. • Work closely with multiple teams across Discovery and DMPK-BA to support bioanalysis.
Experience: • Knowledge of protein precipitation, liquid/liquid extraction, and solid phase extraction. • Ability to operate and troubleshoot HPLCs, Leap/CTC PAL autosamplers and triple quad mass spectrometers. • Experience with quantitative bioanalysis of small molecules. • Knowledge of chromatographic and analytical methodologies. • The ideal candidate is detail oriented and committed to generating high-quality results within tight deadlines and across different projects. • Proven ability to work independently or under minimal supervision in a high-throughput environment to design and conduct experiments, interpret, document, and communicate results, as well as in a team environment to collaborate successfully across other groups within R&D. • Experience operating and troubleshooting current LC-MS/MS platforms (Agilent HPLCs, Leap/CTC PAL and ADDA autosamplers, Sciex API-5500/6500 triple quad Mass Spectrometers) and software (e.g. Discovery Quant, Analyst, Electronic notebook) is highly preferred.
Skills: • Experience with quantitative bioanalysis of small molecules. • Experience operating and troubleshooting current LC-MS/MS platforms (Agilent HPLCs, Leap/CTC PAL and ADDA autosamplers, Sciex API-5500/6500 triple quad Mass Spectrometers) and software (e.g. Discovery Quant, Analyst, Electronic notebook) is highly preferred.
Education: • B.S. in analytical chemistry or related field years of relevant academic/pharmaceutical industry experience.
About US Tech Solutions:
US Tech Solutions is a global staff augmentation firm providing a wide range of talent on-demand and total workforce solutions. To know more about US Tech Solutions, please visit www.ustechsolutions.com.
US Tech Solutions is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, or status as a protected veteran.