The Zepeda-Orozco Lab focus is on Onco-nephrology and use of biomarkers to identify specific kidney injury phenotypes for targeted therapeutic approaches. Her laboratory uses pre-clinical models and human samples to develop mitochondrially targeted therapeutic approaches leveraging tumor and normal cells metabolism differences to protect from chemotherapy and radiation induced nephrotoxicity without protecting tumor cells.
The Post Doctoral Scientist will work under the mentorship of an established CRI principal investigator or Senior Research Scientists to design experiments and develop protocols to conduct research to understand kidney toxicity associated with using radiopharmaceuticals in different preclinical models. The Post Doctoral Scientist will work with advanced cell and tissue culture techniques and perform animal experiments in various models to apply diverse experimental methods, including molecular biology, cell biology, and biochemistry.
The Post Doctoral Scientist will collect and analyze samples, compile results, prepare reports, present findings in lab meetings, participate in journal club, prepare abstracts and poster presentations for scientific conferences, and assist the PI in developing scientific publications and grant proposals. The Post Doctoral Scientist will perform routine laboratory duties to ensure the laboratory is appropriately maintained and supplied. The Post Doctoral Scientist will work with a goal of becoming independent in his/her research effort, and eventually obtaining external research funding. Appointment as a Post Doc is a maximum of 5 years in length.
What Will You Be Doing?
With guidance from a mentor, design experiments and develops protocols required to conduct productive research in a specific scientific area. After the study has been designed, performs the research work in accordance with the protocol.
Helps to train and supervise technical support staff in performing specific techniques essential to carrying out the research program.
Records and analyzes data generated by the research study and helps to plan future research endeavors.
Prepares scientific and technical papers from the results of the research work. Publishes papers in appropriate refereed scientific journals. Presents findings at local (particularly CRI research meetings) and national research forums.
If appropriate, collaborates with other ongoing research efforts either at CRI or at The Ohio State University.
This is considered a training position therefore the RI will allow a trainee 5 years to advance beyond the level of Post Doc.
Works toward research independence. Prepares to submit proposals to and obtain funding from external granting agencies.
What We Are Looking For?
PhD or Medical Degree in Biomedical Sciences, Molecular Biology, Cell Biology, toxicology, pharmacology or related field is required.
Necessary technical skills required include development of xenografts and allograft tumor models in mice, drug administration, and experience with basic laboratory techniques - real-time PCR, immunostaining, immunophenotyping, ELISA, western blot, flow cytometry, fluorescence microscopy, and cell/tissue culture.
Skillsets preferred include experience with radiopharmaceuticals and/or radiation therapies.
Ability to do technical writing, scientific manuscripts writing, and good communication skills for presentation of their work in meetings.
Minimum Physical Requirements:
Percent of time spent on:
25% Designing and developing protocols
25% Performing research work
25% Recording and analyzing data generated by research study
10% Preparing scientific and technical papers
03% Liaison with OSU researchers
02% Miscellaneous paperwork associated with research