In-Vitro Senior Scientist, Oncology Bioscience at AstraZeneca in Waltham, Massachusetts

Job Description:

In-Vitro Senior Scientist, Oncology Bioscience




Location: Waltham, MA




About the Opportunity:



We are seeking a highly motivated Senior Scientist with deep scientific and technical expertise in oncology research to join our Oncology R&D team. This individual will play a crucial role in advancing oncology projects through the drug discovery and development process. Your expertise in tumor biology/immunology will be key to establishing assay systems and delivering high-quality datasets that directly impact targeted therapeutic strategies.



Key Responsibilities:

• Design, conduct, and analyze in vitro experiments to assess the efficacy of candidate oncology drugs.


• Contribute to the discovery and development of novel combination therapies and innovative platforms (e.g. tumor/effector T cell co-culture) to evaluate drug activities.


• Review emerging literature and internal data to identify potential new targets and support target validation activities.


• Collaborate with cross-functional teams of scientists to ensure efficient project progression and data delivery.


• Communicate findings clearly and comprehensively, with a strong understanding of their implications within the broader drug discovery process.


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Basic Qualifications:

• MS with 5+ years or PhD with 2+ years of experience in Biology, Oncology, Tumor Immunology, or a related scientific field.


• 3+ years of experience in industry or academia running and/or overseeing in vitro studies of human tumor cell function (e.g., cell culture, cell signaling bioassays, high-content imaging, cell death assays in primary and cell line cultures).


• Strong background in anti-cancer targeted therapies with a deep understanding of solid tumor models.


• Expertise in molecular biology techniques, including intracellular signaling analysis, engineered cell line generation, and transcriptomic data analysis.


• Strong data reporting skills with an emphasis on clarity and interpretation within the drug discovery context.


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Preferred Qualifications:

• 2+ years of experience in drug discovery programs.

• 1+ years of experience in tumor immunology drug research and discovery.


• Strong interpersonal and collaboration skills, with a track record of problem-solving and effective teamwork in a collaborative environment.

Site Description



Our Waltham, MA facility builds life-changing medicines for people around the world. The modern, vibrant scientific campus employs more than 800 experts in our field, and it is only a short drive from Boston, MA. It is filled with innovative technology. Our work areas were built to facilitate teamwork, interaction and cross functional science. We believe employees benefit from being challenged and inspired at work.


The Boston R&D site, located in Waltham, MA, is situated within a biopharma cluster of academic research institutions, medical centers, pharmaceutical companies and biotech startups. The Boston region is consistently ranked #1 globally for biotech research, investment, talent recruitment and lab space. Site amenities include:

• Modern 64-acre campus nestled in 200+ acres of nature conservation land & hiking trails


• Flexible, agile lab design with co-located write-up space


• Vibrant site community with activities, clubs, sports & games


• Onsite business & meeting center, office, AV & catering support


• Onsite outdoor activities (e.g. frisbee golf, garden club, volleyball, etc.)

Why AstraZeneca?



At AstraZeneca when we see an opportunity for change, we seize it and make it happen, because any opportunity no matter how small, can be the start of something big. Delivering life-changing medicines is about being daring - finding those moments and recognizing their potential. Join us on our journey of building a new kind of organization to reset expectations of what a bio-pharmaceutical company can be. This means we're opening new ways to work, pioneering innovative methods and bringing unexpected teams together. Interested? Come and join our journey.



So, what's next?



Are you already inspiring yourself joining our team? Are you ready to bring new insights and fresh thinking to the table? Good, because we can't wait to hear from you!


The annual base salary for this position ranges from $105,000 to $158,000. However, base pay offered may vary depending on multiple individualized factors, including market location, job-related knowledge, skills, and experience. In addition, our positions offer a short-term incentive bonus opportunity; eligibility to participate in our equity-based long-term incentive program (salaried roles) or to receive a retirement contribution (hourly roles). Benefits offered included a qualified retirement program [401(k) plan]; paid vacation and holidays; paid leaves; and, health benefits including medical, prescription drug, dental, and vision coverage in accordance with the terms and conditions of the applicable plans. Additional details of participation in these benefit plans will be provided if an employee receives an offer of employment. If hired, employee will be in an "at-will position" and the Company reserves the right to modify base salary (as well as any other discretionary payment or compensation program) at any time, including for reasons related to individual performance, Company or individual department/team performance, and market factors.


AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements. Apply Now