Job Description:
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The Pharmacoanalytical Shared Resource (PhASR) supports various clinical trials and drug development projects through the development and utilization of bioanalytical assays for ELISA and LC-MS/MS methodologies according to FDA guidance. This position is a term position with the potential to extend beyond the one year term. The Senior Researcher will be responsible for:
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The application of in-depth knowledge of analytical chemistry and bioanalytical methodologies to drive efficient project design and implementation.
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The development and validation of analytical assays using LC-MS/MS, ELISA, or other appropriate analytical platforms according to FDA guidelines.
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Managing projects, supervising individual contributors in assay development and validation, and guiding/leading less experienced researchers.
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Planning, development, and management of analytical methods to quantitatively characterize mechanisms of absorption, distribution, metabolism, and excretion of novel drugs or drug candidates.
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Troubleshooting and maintenance of LC-MS/MS systems.
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The preparation of biological specimens by protein precipitation, phospholipid removal, liquid-liquid and solid phase extraction for ELISA and LC-MS/MS analyses, and for analysis by other methods as appropriate.
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Leading and training less experienced researchers on the preparation of biological tissues for experimental studies.
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Leading and participating in the development of study-related goals.
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Development and testing of experimental designs, sampling techniques and analytical methods to make recommendations for implementation.
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Researching published studies and incorporating new knowledge and information into PhASR projects.
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Maintaining accurate and detailed research records, including a laboratory notebook, method, and project related documentation.
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Consulting and collaborating with principal investigators to guide bioanalytical and pharmacology aspects of their research.
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Performing FDA Bioanalytical method validation on newly developed and existing methods.
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Working with the technical director to ensure adherence to strict quality control standards by serving as a quality control reviewer.
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Establishing quality control standards for developed analytical assays in adherence with the FDA guidance.
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Developing of SOPs and maintaining laboratory equipment by performing routine maintenance and scheduling contracted maintenance services when necessary.
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Generating invoices, tracking expenses, and producing quotes for analytical services.
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Assisting with day-to-day operations including receipt of samples and packages while completing appropriate documentation.
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Following established laboratory safety procedures to ensure compliance with OSHA regulations and local, state, and federal regulations.
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Preparing method and project reports, research papers and manuscripts for publication and presentation at national conferences and workshops.
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Serving as a resource for less experienced scientists.
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Training and supervising other staff on developed protocols, equipment, and laboratory procedures.
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Performing additional duties as assigned.
Minimum Qualifications
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PhD in chemistry, biochemistry, pharmacology, or science related field.
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7 - 10 years of experience with sample preparation and analysis using ELISA, LC-MS/MS, or flow cytometry.
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Hands-on experience with the development of LC-MS/MS or ELISA analytical methods.
Desired:
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Clinical sample analysis and/or FDA bioanalytical method validation would be preferred, but not required.
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8 - 12 years of relevant experience preferred.
Function: Research and Scholarship
Sub Function: Research
Career Band: Individual Contributor - Specialized
Career Level: S4
Additional Information:
The Ohio State University is an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability status, or protected veteran status.
The Ohio State University is a dynamic community of diverse resources, where opportunity thrives and where individuals transform themselves and the world. The Ohio State University is one of the nation's largest and most comprehensive public universities and a top employer in Ohio.
As one of only 54 designated comprehensive cancer centers in the nation, The Ohio State University Comprehensive Cancer Center - Arthur G. James Cancer Hospital and Richard J. Solove Research Institute is dedicated to the creation of knowledge in laboratory, clinical and population-based cancer research. We apply those discoveries to develop more effective approaches to cancer prevention, diagnosis, and therapies - providing tomorrow's standard of care today. A Cancer-Free World Begins Here.
The OSUCCC - James is the only cancer program in the United States that features a National Cancer Institute (NCI)-designated comprehensive cancer center aligned with a nationally ranked academic medical center and a freestanding cancer hospital on the campus of one of the nation's largest public universities. is the only cancer program in the United States that features a National Cancer Institute (NCI)-designated comprehensive cancer center aligned with a nationally ranked academic medical center and a freestanding cancer hospital on the campus of one of the nation's largest public universities.
Salary Range for this position: $87,400 - $115,000
Shift:First Shift
Final candidates are subject to successful completion of a background check. A drug screen or physical may be required during the post offer process.
Thank you for your interest in positions at The Ohio State University and Wexner Medical Center. Once you have applied, the most updated information on the status of your application can be found by visiting the Candidate Home section of this site. Please view your submitted applications by logging in and reviewing your status. For answers to additional questions please review the frequently asked questions.
The Ohio State University is an equal opportunity employer.
All qualified applicants will receive consideration for employment without regard to age, ancestry, color, disability, ethnicity, gender identity or expression, genetic information, HIV/AIDS status, military status, national origin, race, religion, sex, gender, sexual orientation, pregnancy, protected veteran status, or any other basis under the law.
Applicants are encouraged to complete and submit the Equal Employment Identification form.
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