Scientist, Bioscience at AstraZeneca in Waltham, Massachusetts

Job Description:

Scientist, Bioscience




Waltham, MA



Are you a highly motivated and independent Scientist with a background in Cellular Therapy, Immunology, and/or Immune-Oncology? If so, we have an exciting opportunity for you to contribute to the advancement of innovative Cell Therapy products. This role involves designing and conducting laboratory experiments, developing methodology, and generating and interpreting scientific data in a highly collaborative environment.



Accountabilities:



As a Scientist, you will be responsible for conducting hands-on culturing, expanding, and banking of primary immune cells and tumor cell lines. You will support in vitro efforts towards target cells and immune effector cells engineering, including lentiviral transduction, electroporation-mediated transfection. You will also perform multi-color flow cytometry analysis to evaluate effector/target populations, phenotype and function. Additionally, you will contribute to experimental plans and designs, assess and report data with high integrity, and work collaboratively with project managers to ensure efficient relay of information.



Essential Skills/Experience:

• MS in a relevant scientific field and minimum of 3 years of research experience in molecular and cellular biology of T lymphocytes, cytokine signaling, cancer biology, tumor microenvironment or BS in a relevant scientific field and 3- 5 years of research experience in molecular and cellular biology of T lymphocytes, cytokine signaling, cancer biology, tumor microenvironment


• Hands-on experience in the cell culture of established cell lines and primary human immune cells


• Hands-on experience with T-cell functional assays including in vitro cytotoxicity assays, proliferation, cytokine measurement.


• Experience with multi-color flow cytometry experiment design, acquisition, and analysis

Desirable Skills/Experience:

• Previous experience in the development of CAR-T cells, TCR-T cells


• Familiarity with gene editing techniques (e.g.CRISPR/Cas, viral engineering, base editing)


• Biotechnology or pharmaceutical industry experience preferred

At AstraZeneca's Oncology R&D department, we are united in our vision to eliminate cancer as a cause of death. We are pioneers in our field, making bold moves that transform the way cancer is treated and truly improve patient outcomes. With one of the broadest and deepest Oncology pipelines in the industry, there are many opportunities to work with new and novel drugs and help discover what's next. We foster a mindset of courage, where everyone is empowered to step up, innovate and work at pace. We lead through true collaboration, building collective wisdom by giving everyone a chance to input. It's science with an impact-making a difference for patients and people around the world.



About the Waltham Site



Our Waltham, Massachusetts facility develops life changing small-molecule research in North America, with innovative laboratories at the Gatehouse Park BioHub, just west of the city center. Our BioHub facility, is a bold new R&D initiative, which fosters life science discoveries and the exchange of ideas. Here, we play host to some of the most cutting-edge technology and lab spaces, all designed to inspire collaboration and cross-functional science. We believe employees benefit from being challenged and inspired at work. We are dedicated to creating a culture of inclusion and collaboration. With a shuttle bus to and from Alewife station, the location provides you the ability to work in the heart of one of the world's most vibrant research centers.


Our Waltham site offers a variety of amenities to help book productivity and help keep our employees happy and engaged. This includes a fitness center, employee healthcare clinic, electric vehicle charging stations, dry cleaning, full-service cafeteria and copy center. This is where you'll find newly-designed, activity-based work spaces to suit a variety of working styles while increasing collaboration between teams and the greater research community.


As AstraZeneca continues to put patients at the forefront of our mission, we are excited for our move to Kendall Square/Cambridge in 2026. Find out more information here: Kendall Square Press Release


Ready to take our leading Oncology pipeline to the next level? Apply now to join our team!


If you're curious to know more, please contact Bobbi Poole, our Talent Acquisition Partner.



Closing Date: November 29, 2024




Competitive remuneration and benefits apply



We offer a competitive Total Reward program including a market driven base salary, bonus and long term incentive. We have a generous paid time off program and a comprehensive benefits package.



Where can I find out more?




Our Social Media, Follow AstraZeneca on LinkedIn https://www.linkedin.com/company/1603/



Follow AstraZeneca on Facebook https://www.facebook.com/astrazenecacareers/



Follow AstraZeneca on Instagram
https://www.instagram.com/astrazeneca_careers/?hl=en



AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We follow all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements.


We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation.


AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements. Apply Now