We are looking for a Senior or Principal Scientist to lead our Immunology and Immunoprofiling team. This team develops, validates, implements, and continuously improves cutting-edge analytical platforms to evaluate a patient's immune status, including multi-parameter flow cytometry, and blood-based next generation DNA and RNA sequencing. This candidate will manage the immunology test portfolio, including all cell-based cytometry and NGS assays ensuring the highest standards of quality, efficiency, and innovation. This position will require a deep understanding of existing and emerging immunoprofiling technologies. This candidate will need to possess exceptional operational management skills, self-motivation to drive continuous improvement in a dynamic, fast-paced environment, and serve as a critical immunology product development driver. The candidate will supervise all blood-based assays used for clinical trial support, academic collaborations, and fee-for-service projects.
Key Responsibilities:
Flow Cytometry Assay Development & Quality Control
Assist in the development, optimization, and standardization of flow cytometry assays for the analysis of immune cell populations from patient blood and PBMCs.
Uphold stringent quality control and quality assurance protocols to ensure consistency and reproducibility in flow cytometry data.
Evaluate and monitor performance metrics to maintain the highest quality of data, ensuring reliable and actionable insights for immunological studies.
Troubleshoot and resolve technical issues related to flow cytometry instrumentation and protocols to minimize operational downtime and enhance lab efficiency.
Technology and Innovation in Immunology, Immuno-Oncology, and Flow Cytometry
Stay current with advancements in immunology, immuno-oncology, flow cytometry, and cell-focused technologies.
Collaborate with R&D leadership to assess, implement, and validate new methodologies to maintain a leading edge in immunological research and clinical trial support.
Drive continuous improvement and analytical validation of flow cytometry platforms and methods to ensure top-tier performance in clinical and research settings.
Cross-Functional Collaboration
Collaborate with internal teams, including clinical operations, bioinformatics, and other R&D platforms, to support the integration and deployment of flow cytometry assays in commercial and research projects.
Work closely with external partners, vendors, and regulatory bodies as necessary to ensure alignment with industry standards and compliance requirements.
Partner with project management and alliance teams to define project scope, assess feasibility, and ensure alignment with company goals.
Leadership and Strategy
Execute strategic plans for NGS operations to support the company's NGS product portfolio, support clinical trials, collaborations, and internal R&D assay development.
Lead, mentor, and manage a high-performing team of scientists, laboratory technicians, and bioinformaticians.
Foster a culture of innovation, collaboration, and excellence within the NGS teams in the BG laboratory.
Budget and Resource Management
Oversee budgeting for immunology assay development and process improvements, ensuring efficient use of resources.
Manage procurement, inventory, and maintenance of flow cytometry equipment and reagents to support lab operations and control costs.
Implement cost-saving measures without compromising data integrity or assay quality.
Preferred Skills:
Flow Cytometry Expertise:
Extensive experience with multi-parameter flow cytometry, including panel design, cell sorting, data analysis, and interpretation of immune cell populations.
Deep understanding of cellular phenotypes and immunological signatures, within clinical and translational research contexts.
Assay Development & Tech Transfer:
Proven experience designing, validating, and transferring flow cytometry and immunology assays from R&D to clinical operations teams.
Team Management & Effective Communication:
Demonstrated ability to lead interdisciplinary teams and communicate complex data effectively in person or in writing to cross-functional teams and external stakeholders.
Adaptability & Initiative:
Proactive, self-driven, and highly organized, with the ability to thrive in a fast-paced environment with shifting priorities.
Qualifications:
Ph.D. in Immunology, Immuno-oncology, or a related field, with 5-10 years of experience in assay development, validation, and/or clinical biomarker discovery.
Strong background in flow cytometry, with a history of successful application to research or clinical settings.
Familiarity of bioinformatics tools and data analysis approaches relevant to flow cytometry and next generation sequencing-based analysis.
Experience in a regulated lab environment (e.g., CLIA, CAP, GCLP) with knowledge of regulatory compliance for clinical trials.
Strong leadership, communication, and interpersonal skills, with a track record of mentoring and developing scientific talent.
Knowledge of supply chain management and cost-effective resource allocation to execute complex projects on time and within budget.
Experience with regulatory compliance.
About BOSTONGENE:
BostonGene is pioneering the development of AI-driven biomedical software for the analysis of multi-omic data from cancer patients on the individual and cohort level. To support this mission, we have a cutting-edge high-complexity molecular laboratory that generates large volumes of high quality data, and a state-of-the-art dry lab staffed by an unparalleled team of data scientists and bioinformaticians. This service is used by our biopharma partners to provide custom solutions for clinical trials; from biomarker discovery to companion diagnostic development. We provide immediate diagnostic solutions for clinicians, such as our Tumor PortraitTM test to tailor optimal treatment strategies to improve cancer patient outcomes.