Co-op, Gene Therapy Immunogenicity at Biogen in Cambridge, Massachusetts

Job Description:

Job Description

This application is for a 6-month student role from July - December 2025. Resume review begins in January 2025. 

The Gene Therapy Accelerator Unit (GTxAU)'s remit is to develop safe and efficacious gene therapies for patients with neurological and rare diseases. The Performance team within GTxAU supports this mission by evaluating viral and non-viral gene therapy attributes, their performance in vivo (biodistribution, expression) and immune responses following administration of gene therapies. Furthermore, we are focused on limiting undesirable immune responses to gene therapies to improve the safety and performance of gene therapies in the clinic.  

Position Description 

In this position, you will partner with project teams to define scientific questions to generate testable immunogenicity mitigation strategies. You'll be responsible for designing, executing and interpreting in vitro and in vivo experiments. You will record all protocols, data and conclusions in your electronic laboratory notebook and present results at internal meetings.   

Example projects may include: 

• Evaluation of plasmacytoid dendritic cell's role in CD8+ T cell responses to AAV capsid 


• In vivo testing of pharmacologic agents to prevent de novo antibody responses to AAV capsid 


• Establish in vitro assays to interrogate innate immune responses to various LNP-mRNA gene therapies  

Qualifications

• Proficient in molecular and cell biology techniques (DNA/RNA extraction, cell culture and aseptic technique, ELISAs, and western blotting) 


• In vivo experience with basic rodent handling and tissue collection and processing 


• Experienced in flow cytometry  


• Strong critical thinking, organization and communication skills  

To participate in the Biogen Internship Program, students must meet the following eligibility criteria: 

• Legal authorization to work in the U.S. 


• At least 18 years of age prior to the scheduled start date 


• Be currently enrolled in an accredited community college, college or university, with a graduation date no earlier than December 2025.

Education 

• B.S. in Biology or Life Sciences related majors. Currently enrolled in a M.S. or Ph.D. program, preference for those with a focus in Immunology or Neuroimmunology.  

Location

• This position is on-site in Cambridge, MA.

Additional Information

Why Biogen?

We are a global team with a commitment to excellence, and a pioneering spirit. As a mid-sized biotechnology company, we provide the stability and resources of a well-established business while fostering an environment where individual contributions make a significant impact. Our team encompasses some of the most talented and passionate achievers who have unparalleled opportunities for learning, growth, and expanding their skills. Above all, we work together to deliver life-changing medicines, with every role playing a vital part in our mission. Caring Deeply. Achieving Excellence. Changing Lives.

At Biogen, we are committed to building on our culture of inclusion and belonging that reflects the communities where we operate and the patients we serve. We know that diverse backgrounds, cultures, and perspectives make us a stronger and more innovative company, and we are focused on building teams where every employee feels empowered and inspired. Read on to learn more about our DE&I efforts.

All qualified applicants will receive consideration for employment without regard to sex, gender identity or expression, sexual orientation, marital status, race, color, national origin, ancestry, ethnicity, religion, age, veteran status, disability, genetic information or any other basis protected by federal, state or local law. Biogen is an E-Verify Employer in the United States.

 

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