Stealth-mode biotech in Cambridge founded by a blue-chip investor is seeking a highly motivated Scientist to join the discovery group. The candidate should have a strong background in immunology with a deep understanding of the pathogenic mechanisms of autoimmunity and inflammation.
We are seeking collaborative individuals, who have a strong work ethic and can thrive in a fast-paced environment. This is an excellent opportunity for an individual to drive discovery efforts of novel and next-generation therapeutics for an array of immunological disorders.
Key Responsibilities
Use patient samples and design and execute experiments in vitro/in vivo to prioritize drug candidates preclinically
Identify suitable disease models of inflammatory disease, design and oversee in vivo experiments to address the mechanism of action of the drug candidates
Oversee in vivo experiments in animal models of immune-mediated diseases and perform ex vivo experiments with blood and tissues from the models
Analyze and summarize the data
Organize experiments and results in the Electronic Lab Notebook (ELN)
Assist or execute experiments, analyze data, and present to various stakeholders
Manage and mentor research associates
Demonstrate scientific rigor, maintain electronic lab notebooks, and comply with good laboratory practices
Collaborate within the team and cross-functionally as necessary to advance projects and meet company milestones
Minimum Qualifications
Ph.D in the field of biology, immunology, or a related discipline with 1+ years of industry experience
Experience in animal models of inflammation or allergy
Strong background in T and B cell biology is preferred
Proficiency with various immunological techniques including but not limited to multicolor flow cytometry, ICS, cytotoxicity assays, cytokine bead array, ELISpot, MSD etc.
Excellent tissue culture techniques including isolation and culture of various cell types from primary human cells, humanized mice, or NHP
Prior experience with biologics or antibody-based therapies is desirable