Early is Good (EIG) is developing non-invasive, multiomic based tests to improve the accuracy and accessibility of cancer detection. Our proprietary ultra-sensitive nanotechnology platform uses multiomic biomarker detection to generate highly-sensitive, fast, and cost effective results at the earliest stage of disease.
We are looking for a Nanoparticle Bioconjugation Scientist with extensive experience in metallic nanoparticle, bioconjugation, surface chemistry, and assay development. You'll be a key player in designing, developing, and scaling nanoparticle-based assays and surface modification strategies for high-sensitivity diagnostics. You'll also work closely with our cross-functional team to push the limits of cancer diagnostics.
Your responsibilities will include
Design and execute bioconjugation processes using various chemistries, including NHS/EDC, click chemistry, amide, ester, azide, thiol-maleimide reactions, etc.
Develop and optimize functionalization strategies for metallic nanoparticles using advanced surface chemistry techniques such as PEGylation, biotinylation, and covalent coupling with antibodies, antigens, nucleic acids, and small molecules.
Perform advanced physicochemical characterization of metallic nanoparticles and bioconjugates using DLS, TEM, SEM, FTIR, NMR, UV-Vis, and HPLC/UPLC.
Optimize protocols for metallic nanoparticle functionalization, including iron oxide and colloidal gold.
Troubleshoot and improve bioconjugation processes to enhance stability, sensitivity, and specificity.
Collaborate with product development and scale-up teams to ensure consistent performance in metallic nanoparticle assays.
Maintain detailed experiment records, contribute to reports, and share insights with the team.
Must have:
Ph.D/MsC. in Biochemistry, Chemistry, Materials Science, or a related field, focused on metallic nanoparticle bioconjugation with 5+ years of industrial experience.
Strong expertise in metallic nanoparticle surface modification and functionalization.
Hands-on experience with various conjugation chemistries, including thiol, amine, acid, azide, and other click chemistries.
Proven success in developing particle-based immunoassays, like ELISA and lateral flow.
Solid background in analytical methods for characterizing metallic nanoparticles.
Ability to work effectively as part of a cross-functional team.
Nice to have:
Expertise in multistep organic synthesis, including the development of small organic molecules, macromolecules, and polymers.
Experience with scaling metallic nanoparticle products for FDA-regulated markets.
Background in developing in vitro diagnostic assays, especially in oncology applications.