Job Description:
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Location: Remote (within 1 hour of Cambridge, MA)
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Duration: 6+ Months Contract
Requirements:
- PhD in Structural Biology, Bioinformatics, Biochemistry, or related field + 3+ years of biotech/pharma experience.
- Expertise in Rosetta, AlphaFold, ESMFold, RFdiffusion, ProteinMPNN.
- Strong ML background (RNNs, GNNs, Transformers, NLP, Generative AI).
- Experience with GROMACS, AmberTools, AutoDock for molecular dynamics and docking.
- Proficiency in Python, R, SQL, PyTorch, TensorFlow, JAX, scikit-learn.
- Experience with cloud computing, APIs, and large-scale data systems.
- Strong communication and teamwork skills.
Responsibilities:
- Develop ML-based protein design models for structure, function, and dynamics analysis.
- Design targeting ligands/delivery vectors (AAVs, peptides, antibodies) for RNA and gene therapies.
- Build predictive models for exon skipping and genetic mutation effects.
- Support pre-clinical/clinical research using structural biology methods.
- Enhance in-house protein structure prediction tools.