Scientist, Chem & Mol Therapeutics at Biogen in Cambridge, Massachusetts

Job Description:

Job Description

About This Role  

The BioDesign Protein Biohemistry group at Biogen is seeking a creative and self-motivated scientist to contribute to our mission to design and develop medicines to transform patients' lives. The successful candidate will play a key role in designing, generating, and characterizing antibody-oligonucleotide conjugates intended to improve the delivery of therapeutic oligonucleotides (ASOs or siRNAs) to target tissues.  This role requires a strong background in protein chemistry with extensive experience in bioconjugation and a deep understanding of linker design and optimization to improve the stability, efficiency, and efficacy of antibody-oligonucleotide conjugates. 

What You'll Do 

• Optimize and implement protein purification schemes for engineered antibodies using computer-interfaced chromatography systems (e.g., AKTA or similar) 

• Characterize proteins using standard methods such as SDS-PAGE, analytical size-exclusion chromatography, and dynamic light scattering 

• Work with a cross-functional team to design and test novel linker chemistries to enhance conjugate stability and performance 

• Develop and optimize novel antibody-oligonucleotide conjugation and purification methods 

• Generate, purify, and analyze antibody-drug conjugates for use in animal models. 

• Actively contribute to project strategy and experimental design, and regularly present findings at team meetings 

• Troubleshoot technical challenges and drive continuous improvements in conjugation and purification workflows 

Who You Are 

The ideal candidate has a strong background in bioconjugation methods, a passion for science, and a genuine enthusiasm for collaborating within a cross-functional team. 

Qualifications

Required Skills  

• Ph.D. in biochemistry, chemical biology, chemistry, or a related field with 0-2 years experience, or a Master's degree with 4+ years relevant industry experience. 

• Extensive experience in protein purification, including method development. 

• Strong analytical skills and proficiency with standard protein characterization methods (e.g., SDS-PAGE, size-exclusion chromatography and DLS). 

• Experience with antibody-oligonucleotide conjugation techniques, including click-chemistry and site-specific methods. 

• Demonstrated ability to independently design, plan, execute, and interpret complex experiments. 

• Excellent written and verbal communication skills. 

Preferred Skills 

• Experience with linker design 

• Experience with antibody-oligoconjugate quantitation and stability assays 

Additional Information

The base salary range for this position is $114,000 - $149,000. Base salary offered is determined though an analytical approach utilizing a combination of factors including, but not limited to, relevant skills & experience, job location, and internal equity.  Regular employees are eligible to receive both short term and long-term incentives, including cash bonus and equity incentive opportunities, designed to reward recent achievements and recognize your future potential based on individual, business unit and company performance.   

In addition to compensation, Biogen offers a full and highly competitive range of benefits designed to support our employees and their families' physical, financial, emotional, and social well-being; including, but not limited to:  

• Medical, Dental, Vision, & Life insurances 


• Fitness & Wellness programs including a fitness reimbursement   


• Short- and Long-Term Disability insurance  


• A minimum of 15 days of paid vacation and an additional end-of-year shutdown time off (Dec 26-Dec 31) 


• Up to 12 company paid holidays + 3 days off for Personal Significance 


• 80 hours of sick time per calendar year


• Paid Maternity and Parental Leave benefit 


• 401(k) program participation with company matched contributions 


• Employee stock purchase plan   


• Tuition reimbursement of up to $10,000 per calendar year   


• Employee Resource Groups participation   

Why Biogen?

We are a global team with a commitment to excellence, and a pioneering spirit. As a mid-sized biotechnology company, we provide the stability and resources of a well-established business while fostering an environment where individual contributions make a significant impact. Our team encompasses some of the most talented and passionate achievers who have unparalleled opportunities for learning, growth, and expanding their skills. Above all, we work together to deliver life-changing medicines, with every role playing a vital part in our mission. Caring Deeply. Achieving Excellence. Changing Lives.

At Biogen, we are committed to building on our culture of inclusion and belonging that reflects the communities where we operate and the patients we serve. We know that diverse backgrounds, cultures, and perspectives make us a stronger and more innovative company, and we are focused on building teams where every employee feels empowered and inspired. Read on to learn more about our DE&I efforts.

All qualified applicants will receive consideration for employment without regard to sex, gender identity or expression, sexual orientation, marital status, race, color, national origin, ancestry, ethnicity, religion, age, veteran status, disability, genetic information or any other basis protected by federal, state or local law. Biogen is an E-Verify Employer in the United States.

 

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